Replication defective viral genomes exploit a cellular pro-survival mechanism to establish paramyxovirus persistence

Replication defective viral genomes (DVGs) can facilitate persistence of paramyxoviruses, but the underlying mechanisms are unclear. Using FISH, Xu et al. here analyze the cellular response to DVGs on a single cell level and show that a MAVS-mediated TNF response specifically extends survival of cel...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Jie Xu, Yan Sun, Yize Li, Gordon Ruthel, Susan R. Weiss, Arjun Raj, Daniel Beiting, Carolina B. López
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Q
Acceso en línea:https://doaj.org/article/de04deb85ee9444f8080c1d3da9a63d7
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:de04deb85ee9444f8080c1d3da9a63d7
record_format dspace
spelling oai:doaj.org-article:de04deb85ee9444f8080c1d3da9a63d72021-12-02T17:06:15ZReplication defective viral genomes exploit a cellular pro-survival mechanism to establish paramyxovirus persistence10.1038/s41467-017-00909-62041-1723https://doaj.org/article/de04deb85ee9444f8080c1d3da9a63d72017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00909-6https://doaj.org/toc/2041-1723Replication defective viral genomes (DVGs) can facilitate persistence of paramyxoviruses, but the underlying mechanisms are unclear. Using FISH, Xu et al. here analyze the cellular response to DVGs on a single cell level and show that a MAVS-mediated TNF response specifically extends survival of cells enriched in DVGs.Jie XuYan SunYize LiGordon RuthelSusan R. WeissArjun RajDaniel BeitingCarolina B. LópezNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jie Xu
Yan Sun
Yize Li
Gordon Ruthel
Susan R. Weiss
Arjun Raj
Daniel Beiting
Carolina B. López
Replication defective viral genomes exploit a cellular pro-survival mechanism to establish paramyxovirus persistence
description Replication defective viral genomes (DVGs) can facilitate persistence of paramyxoviruses, but the underlying mechanisms are unclear. Using FISH, Xu et al. here analyze the cellular response to DVGs on a single cell level and show that a MAVS-mediated TNF response specifically extends survival of cells enriched in DVGs.
format article
author Jie Xu
Yan Sun
Yize Li
Gordon Ruthel
Susan R. Weiss
Arjun Raj
Daniel Beiting
Carolina B. López
author_facet Jie Xu
Yan Sun
Yize Li
Gordon Ruthel
Susan R. Weiss
Arjun Raj
Daniel Beiting
Carolina B. López
author_sort Jie Xu
title Replication defective viral genomes exploit a cellular pro-survival mechanism to establish paramyxovirus persistence
title_short Replication defective viral genomes exploit a cellular pro-survival mechanism to establish paramyxovirus persistence
title_full Replication defective viral genomes exploit a cellular pro-survival mechanism to establish paramyxovirus persistence
title_fullStr Replication defective viral genomes exploit a cellular pro-survival mechanism to establish paramyxovirus persistence
title_full_unstemmed Replication defective viral genomes exploit a cellular pro-survival mechanism to establish paramyxovirus persistence
title_sort replication defective viral genomes exploit a cellular pro-survival mechanism to establish paramyxovirus persistence
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/de04deb85ee9444f8080c1d3da9a63d7
work_keys_str_mv AT jiexu replicationdefectiveviralgenomesexploitacellularprosurvivalmechanismtoestablishparamyxoviruspersistence
AT yansun replicationdefectiveviralgenomesexploitacellularprosurvivalmechanismtoestablishparamyxoviruspersistence
AT yizeli replicationdefectiveviralgenomesexploitacellularprosurvivalmechanismtoestablishparamyxoviruspersistence
AT gordonruthel replicationdefectiveviralgenomesexploitacellularprosurvivalmechanismtoestablishparamyxoviruspersistence
AT susanrweiss replicationdefectiveviralgenomesexploitacellularprosurvivalmechanismtoestablishparamyxoviruspersistence
AT arjunraj replicationdefectiveviralgenomesexploitacellularprosurvivalmechanismtoestablishparamyxoviruspersistence
AT danielbeiting replicationdefectiveviralgenomesexploitacellularprosurvivalmechanismtoestablishparamyxoviruspersistence
AT carolinablopez replicationdefectiveviralgenomesexploitacellularprosurvivalmechanismtoestablishparamyxoviruspersistence
_version_ 1718381703751270400