Loss of GCNT2/I-branched glycans enhances melanoma growth and survival

Loss of GCNT2/I-branched glycans enhances melanoma growth and survival

Aberrant glycosylation patterns on cancer cells promote several pro-tumorigenic functions, including enhancing tumor cell proliferation. Here the authors provide data that show melanoma cells downregulate GCNT2 with consequent loss of I-branched glycans; this leads to the formation of extended i-lin...

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Autores principales: Jenna Geddes Sweeney, Jennifer Liang, Aristotelis Antonopoulos, Nicholas Giovannone, Shuli Kang, Tony S. Mondala, Steven R. Head, Sandra L. King, Yoshihiko Tani, Danielle Brackett, Anne Dell, George F. Murphy, Stuart M. Haslam, Hans R. Widlund, Charles J. Dimitroff
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/de097a28a8eb4a7595203ca85b7c7bc9
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Sumario:Aberrant glycosylation patterns on cancer cells promote several pro-tumorigenic functions, including enhancing tumor cell proliferation. Here the authors provide data that show melanoma cells downregulate GCNT2 with consequent loss of I-branched glycans; this leads to the formation of extended i-linear glycans and enhances melanoma growth via increases, in part, by IGF-1- and extracellular matrix-induced signaling.

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