Loss of GCNT2/I-branched glycans enhances melanoma growth and survival

Aberrant glycosylation patterns on cancer cells promote several pro-tumorigenic functions, including enhancing tumor cell proliferation. Here the authors provide data that show melanoma cells downregulate GCNT2 with consequent loss of I-branched glycans; this leads to the formation of extended i-lin...

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Autores principales:	Jenna Geddes Sweeney, Jennifer Liang, Aristotelis Antonopoulos, Nicholas Giovannone, Shuli Kang, Tony S. Mondala, Steven R. Head, Sandra L. King, Yoshihiko Tani, Danielle Brackett, Anne Dell, George F. Murphy, Stuart M. Haslam, Hans R. Widlund, Charles J. Dimitroff
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/de097a28a8eb4a7595203ca85b7c7bc9
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spelling	oai:doaj.org-article:de097a28a8eb4a7595203ca85b7c7bc92021-12-02T15:33:45ZLoss of GCNT2/I-branched glycans enhances melanoma growth and survival10.1038/s41467-018-05795-02041-1723https://doaj.org/article/de097a28a8eb4a7595203ca85b7c7bc92018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05795-0https://doaj.org/toc/2041-1723Aberrant glycosylation patterns on cancer cells promote several pro-tumorigenic functions, including enhancing tumor cell proliferation. Here the authors provide data that show melanoma cells downregulate GCNT2 with consequent loss of I-branched glycans; this leads to the formation of extended i-linear glycans and enhances melanoma growth via increases, in part, by IGF-1- and extracellular matrix-induced signaling.Jenna Geddes SweeneyJennifer LiangAristotelis AntonopoulosNicholas GiovannoneShuli KangTony S. MondalaSteven R. HeadSandra L. KingYoshihiko TaniDanielle BrackettAnne DellGeorge F. MurphyStuart M. HaslamHans R. WidlundCharles J. DimitroffNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jenna Geddes Sweeney Jennifer Liang Aristotelis Antonopoulos Nicholas Giovannone Shuli Kang Tony S. Mondala Steven R. Head Sandra L. King Yoshihiko Tani Danielle Brackett Anne Dell George F. Murphy Stuart M. Haslam Hans R. Widlund Charles J. Dimitroff Loss of GCNT2/I-branched glycans enhances melanoma growth and survival
description	Aberrant glycosylation patterns on cancer cells promote several pro-tumorigenic functions, including enhancing tumor cell proliferation. Here the authors provide data that show melanoma cells downregulate GCNT2 with consequent loss of I-branched glycans; this leads to the formation of extended i-linear glycans and enhances melanoma growth via increases, in part, by IGF-1- and extracellular matrix-induced signaling.
format	article
author	Jenna Geddes Sweeney Jennifer Liang Aristotelis Antonopoulos Nicholas Giovannone Shuli Kang Tony S. Mondala Steven R. Head Sandra L. King Yoshihiko Tani Danielle Brackett Anne Dell George F. Murphy Stuart M. Haslam Hans R. Widlund Charles J. Dimitroff
author_facet	Jenna Geddes Sweeney Jennifer Liang Aristotelis Antonopoulos Nicholas Giovannone Shuli Kang Tony S. Mondala Steven R. Head Sandra L. King Yoshihiko Tani Danielle Brackett Anne Dell George F. Murphy Stuart M. Haslam Hans R. Widlund Charles J. Dimitroff
author_sort	Jenna Geddes Sweeney
title	Loss of GCNT2/I-branched glycans enhances melanoma growth and survival
title_short	Loss of GCNT2/I-branched glycans enhances melanoma growth and survival
title_full	Loss of GCNT2/I-branched glycans enhances melanoma growth and survival
title_fullStr	Loss of GCNT2/I-branched glycans enhances melanoma growth and survival
title_full_unstemmed	Loss of GCNT2/I-branched glycans enhances melanoma growth and survival
title_sort	loss of gcnt2/i-branched glycans enhances melanoma growth and survival
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/de097a28a8eb4a7595203ca85b7c7bc9
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Loss of GCNT2/I-branched glycans enhances melanoma growth and survival

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