Overexpressed somatic alleles are enriched in functional elements in Breast Cancer
Abstract Asymmetric allele content in the transcriptome can be indicative of functional and selective features of the underlying genetic variants. Yet, imbalanced alleles, especially from diploid genome regions, are poorly explored in cancer. Here we systematically quantify and integrate the variant...
Saved in:
Main Authors: | Paula Restrepo, Mercedeh Movassagh, Nawaf Alomran, Christian Miller, Muzi Li, Chris Trenkov, Yulian Manchev, Sonali Bahl, Stephanie Warnken, Liam Spurr, Tatiyana Apanasovich, Keith Crandall, Nathan Edwards, Anelia Horvath |
---|---|
Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2017
|
Subjects: | |
Online Access: | https://doaj.org/article/de12aae9e1cb49908e4868f2314b57c1 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Allelic imbalance of somatic mutations in cancer genomes and transcriptomes
by: Je-Keun Rhee, et al.
Published: (2017) -
KCC2 overexpression prevents the paradoxical seizure-promoting action of somatic inhibition
by: Vincent Magloire, et al.
Published: (2019) -
Identification of somatic mutations in single cell DNA-seq using a spatial model of allelic imbalance
by: Lovelace J. Luquette, et al.
Published: (2019) -
Confirming putative variants at ≤ 5% allele frequency using allele enrichment and Sanger sequencing
by: Yan Helen Yan, et al.
Published: (2021) -
Sensitive detection of EBV microRNAs across cancer spectrum reveals association with decreased survival in adult acute myelocytic leukemia
by: Mercedeh Movassagh, et al.
Published: (2019)