Continuous transcription initiation guarantees robust repair of all transcribed genes and regulatory regions

A transcription-driven cellular response is activated upon UV stress. Here the authors reveal mechanistic insights into the regulatory process affecting transcription and chromatin dynamics, showing how maintaining Pol II firing safeguards the integrity of cells’ transcriptome

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Autores principales:	Anastasios Liakos, Dimitris Konstantopoulos, Matthieu D. Lavigne, Maria Fousteri
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/de13ff9326e049b98166cdb29b54b7f9
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spelling	oai:doaj.org-article:de13ff9326e049b98166cdb29b54b7f92021-12-02T15:39:13ZContinuous transcription initiation guarantees robust repair of all transcribed genes and regulatory regions10.1038/s41467-020-14566-92041-1723https://doaj.org/article/de13ff9326e049b98166cdb29b54b7f92020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14566-9https://doaj.org/toc/2041-1723A transcription-driven cellular response is activated upon UV stress. Here the authors reveal mechanistic insights into the regulatory process affecting transcription and chromatin dynamics, showing how maintaining Pol II firing safeguards the integrity of cells’ transcriptomeAnastasios LiakosDimitris KonstantopoulosMatthieu D. LavigneMaria FousteriNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anastasios Liakos Dimitris Konstantopoulos Matthieu D. Lavigne Maria Fousteri Continuous transcription initiation guarantees robust repair of all transcribed genes and regulatory regions
description	A transcription-driven cellular response is activated upon UV stress. Here the authors reveal mechanistic insights into the regulatory process affecting transcription and chromatin dynamics, showing how maintaining Pol II firing safeguards the integrity of cells’ transcriptome
format	article
author	Anastasios Liakos Dimitris Konstantopoulos Matthieu D. Lavigne Maria Fousteri
author_facet	Anastasios Liakos Dimitris Konstantopoulos Matthieu D. Lavigne Maria Fousteri
author_sort	Anastasios Liakos
title	Continuous transcription initiation guarantees robust repair of all transcribed genes and regulatory regions
title_short	Continuous transcription initiation guarantees robust repair of all transcribed genes and regulatory regions
title_full	Continuous transcription initiation guarantees robust repair of all transcribed genes and regulatory regions
title_fullStr	Continuous transcription initiation guarantees robust repair of all transcribed genes and regulatory regions
title_full_unstemmed	Continuous transcription initiation guarantees robust repair of all transcribed genes and regulatory regions
title_sort	continuous transcription initiation guarantees robust repair of all transcribed genes and regulatory regions
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/de13ff9326e049b98166cdb29b54b7f9
work_keys_str_mv	AT anastasiosliakos continuoustranscriptioninitiationguaranteesrobustrepairofalltranscribedgenesandregulatoryregions AT dimitriskonstantopoulos continuoustranscriptioninitiationguaranteesrobustrepairofalltranscribedgenesandregulatoryregions AT matthieudlavigne continuoustranscriptioninitiationguaranteesrobustrepairofalltranscribedgenesandregulatoryregions AT mariafousteri continuoustranscriptioninitiationguaranteesrobustrepairofalltranscribedgenesandregulatoryregions
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Continuous transcription initiation guarantees robust repair of all transcribed genes and regulatory regions

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