Macrophage membrane camouflaged reactive oxygen species responsive nanomedicine for efficiently inhibiting the vascular intimal hyperplasia

Abstract Background Intimal hyperplasia caused by vascular injury is an important pathological process of many vascular diseases, especially occlusive vascular disease. In recent years, Nano-drug delivery system has attracted a wide attention as a novel treatment strategy, but there are still some c...

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Autores principales:	Boyan Liu, Wenhua Yan, Li Luo, Shuai Wu, Yi Wang, Yuan Zhong, Dan Tang, Ali Maruf, Meng Yan, Kun Zhang, Xian Qin, Kai Qu, Wei Wu, Guixue Wang
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Intimal hyperplasia Nanomedicine Targeted delivery Macrophages ROS-responsive Biotechnology TP248.13-248.65 Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/de17b6f5adb5453baabb43715c6d3fe3
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spelling	oai:doaj.org-article:de17b6f5adb5453baabb43715c6d3fe32021-11-21T12:29:28ZMacrophage membrane camouflaged reactive oxygen species responsive nanomedicine for efficiently inhibiting the vascular intimal hyperplasia10.1186/s12951-021-01119-51477-3155https://doaj.org/article/de17b6f5adb5453baabb43715c6d3fe32021-11-01T00:00:00Zhttps://doi.org/10.1186/s12951-021-01119-5https://doaj.org/toc/1477-3155Abstract Background Intimal hyperplasia caused by vascular injury is an important pathological process of many vascular diseases, especially occlusive vascular disease. In recent years, Nano-drug delivery system has attracted a wide attention as a novel treatment strategy, but there are still some challenges such as high clearance rate and insufficient targeting. Results In this study, we report a biomimetic ROS-responsive MM@PCM/RAP nanoparticle coated with macrophage membrane. The macrophage membrane with the innate “homing” capacity can superiorly regulate the recruitment of MM@PCM/RAP to inflammatory lesion to enhance target efficacy, and can also disguise MM@PCM/RAP nanoparticle as the autologous cell to avoid clearance by the immune system. In addition, MM@PCM/RAP can effectively improve the solubility of rapamycin and respond to the high concentration level of ROS accumulated in pathological lesion for controlling local cargo release, thereby increasing drug availability and reducing toxic side effects. Conclusions Our findings validate that the rational design, biomimetic nanoparticles MM@PCM/RAP, can effectively inhibit the pathological process of intimal injury with excellent biocompatibility. Graphical AbstractBoyan LiuWenhua YanLi LuoShuai WuYi WangYuan ZhongDan TangAli MarufMeng YanKun ZhangXian QinKai QuWei WuGuixue WangBMCarticleIntimal hyperplasiaNanomedicineTargeted deliveryMacrophagesROS-responsiveBiotechnologyTP248.13-248.65Medical technologyR855-855.5ENJournal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Intimal hyperplasia Nanomedicine Targeted delivery Macrophages ROS-responsive Biotechnology TP248.13-248.65 Medical technology R855-855.5
spellingShingle	Intimal hyperplasia Nanomedicine Targeted delivery Macrophages ROS-responsive Biotechnology TP248.13-248.65 Medical technology R855-855.5 Boyan Liu Wenhua Yan Li Luo Shuai Wu Yi Wang Yuan Zhong Dan Tang Ali Maruf Meng Yan Kun Zhang Xian Qin Kai Qu Wei Wu Guixue Wang Macrophage membrane camouflaged reactive oxygen species responsive nanomedicine for efficiently inhibiting the vascular intimal hyperplasia
description	Abstract Background Intimal hyperplasia caused by vascular injury is an important pathological process of many vascular diseases, especially occlusive vascular disease. In recent years, Nano-drug delivery system has attracted a wide attention as a novel treatment strategy, but there are still some challenges such as high clearance rate and insufficient targeting. Results In this study, we report a biomimetic ROS-responsive MM@PCM/RAP nanoparticle coated with macrophage membrane. The macrophage membrane with the innate “homing” capacity can superiorly regulate the recruitment of MM@PCM/RAP to inflammatory lesion to enhance target efficacy, and can also disguise MM@PCM/RAP nanoparticle as the autologous cell to avoid clearance by the immune system. In addition, MM@PCM/RAP can effectively improve the solubility of rapamycin and respond to the high concentration level of ROS accumulated in pathological lesion for controlling local cargo release, thereby increasing drug availability and reducing toxic side effects. Conclusions Our findings validate that the rational design, biomimetic nanoparticles MM@PCM/RAP, can effectively inhibit the pathological process of intimal injury with excellent biocompatibility. Graphical Abstract
format	article
author	Boyan Liu Wenhua Yan Li Luo Shuai Wu Yi Wang Yuan Zhong Dan Tang Ali Maruf Meng Yan Kun Zhang Xian Qin Kai Qu Wei Wu Guixue Wang
author_facet	Boyan Liu Wenhua Yan Li Luo Shuai Wu Yi Wang Yuan Zhong Dan Tang Ali Maruf Meng Yan Kun Zhang Xian Qin Kai Qu Wei Wu Guixue Wang
author_sort	Boyan Liu
title	Macrophage membrane camouflaged reactive oxygen species responsive nanomedicine for efficiently inhibiting the vascular intimal hyperplasia
title_short	Macrophage membrane camouflaged reactive oxygen species responsive nanomedicine for efficiently inhibiting the vascular intimal hyperplasia
title_full	Macrophage membrane camouflaged reactive oxygen species responsive nanomedicine for efficiently inhibiting the vascular intimal hyperplasia
title_fullStr	Macrophage membrane camouflaged reactive oxygen species responsive nanomedicine for efficiently inhibiting the vascular intimal hyperplasia
title_full_unstemmed	Macrophage membrane camouflaged reactive oxygen species responsive nanomedicine for efficiently inhibiting the vascular intimal hyperplasia
title_sort	macrophage membrane camouflaged reactive oxygen species responsive nanomedicine for efficiently inhibiting the vascular intimal hyperplasia
publisher	BMC
publishDate	2021
url	https://doaj.org/article/de17b6f5adb5453baabb43715c6d3fe3
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Macrophage membrane camouflaged reactive oxygen species responsive nanomedicine for efficiently inhibiting the vascular intimal hyperplasia

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