The risk of pulmonary tuberculosis after traumatic brain injury

Abstract After traumatic brain injury (TBI), an inflammatory response in the brain might affect the immune system. The risk of pulmonary infection reportedly increases in patients with TBI. We aimed to evaluate the risk of tuberculosis (TB) in patients with TBI in Taiwan. All participants were selec...

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Autores principales:	Hsin-Yueh Liu, Kuang-Ming Liao, Fu-Wen Liang, Yi-Chieh Hung, Jhi-Joung Wang, Te-Chun Shen, Chung-Han Ho
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/de19ac4fbabe4d448f713e7c6ffdf376
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spelling	oai:doaj.org-article:de19ac4fbabe4d448f713e7c6ffdf3762021-12-02T18:15:24ZThe risk of pulmonary tuberculosis after traumatic brain injury10.1038/s41598-021-87332-62045-2322https://doaj.org/article/de19ac4fbabe4d448f713e7c6ffdf3762021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87332-6https://doaj.org/toc/2045-2322Abstract After traumatic brain injury (TBI), an inflammatory response in the brain might affect the immune system. The risk of pulmonary infection reportedly increases in patients with TBI. We aimed to evaluate the risk of tuberculosis (TB) in patients with TBI in Taiwan. All participants were selected from the intensive care unit (ICU). Patients with TBI were defined as patients in ICU with intracranial injury, and comparison cohort were patients in ICU without TBI diagnosis. There was a significant difference in TB risk between the patients with TBI and the comparison cohort according to age and the Charlson’s comorbidity index (CCI) score. Thus, we divided patients based on CCI into three groups for further analysis: mild (CCI = 0), moderate (CCI = 1/2), severe (CCI > 2). Mild-CCI group had a lower TB incidence rate (0.74%) and longer time to TB development (median: 2.43) than the other two groups. Moderate-CCI group had 1.52-fold increased risk of TB infection (p < 0.0001) compared with mild-CCI group. In the severe-CCI group, patients aged ≥ 80 years had 1.91-fold risk of TB compared with mild-CCI group (p = 0.0481). Severe-CCI group had significantly higher mortality than the mild-CCI group (p = 0.0366). Patients with TBI and more comorbidities had higher risk of TB infection with higher mortality rate.Hsin-Yueh LiuKuang-Ming LiaoFu-Wen LiangYi-Chieh HungJhi-Joung WangTe-Chun ShenChung-Han HoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hsin-Yueh Liu Kuang-Ming Liao Fu-Wen Liang Yi-Chieh Hung Jhi-Joung Wang Te-Chun Shen Chung-Han Ho The risk of pulmonary tuberculosis after traumatic brain injury
description	Abstract After traumatic brain injury (TBI), an inflammatory response in the brain might affect the immune system. The risk of pulmonary infection reportedly increases in patients with TBI. We aimed to evaluate the risk of tuberculosis (TB) in patients with TBI in Taiwan. All participants were selected from the intensive care unit (ICU). Patients with TBI were defined as patients in ICU with intracranial injury, and comparison cohort were patients in ICU without TBI diagnosis. There was a significant difference in TB risk between the patients with TBI and the comparison cohort according to age and the Charlson’s comorbidity index (CCI) score. Thus, we divided patients based on CCI into three groups for further analysis: mild (CCI = 0), moderate (CCI = 1/2), severe (CCI > 2). Mild-CCI group had a lower TB incidence rate (0.74%) and longer time to TB development (median: 2.43) than the other two groups. Moderate-CCI group had 1.52-fold increased risk of TB infection (p < 0.0001) compared with mild-CCI group. In the severe-CCI group, patients aged ≥ 80 years had 1.91-fold risk of TB compared with mild-CCI group (p = 0.0481). Severe-CCI group had significantly higher mortality than the mild-CCI group (p = 0.0366). Patients with TBI and more comorbidities had higher risk of TB infection with higher mortality rate.
format	article
author	Hsin-Yueh Liu Kuang-Ming Liao Fu-Wen Liang Yi-Chieh Hung Jhi-Joung Wang Te-Chun Shen Chung-Han Ho
author_facet	Hsin-Yueh Liu Kuang-Ming Liao Fu-Wen Liang Yi-Chieh Hung Jhi-Joung Wang Te-Chun Shen Chung-Han Ho
author_sort	Hsin-Yueh Liu
title	The risk of pulmonary tuberculosis after traumatic brain injury
title_short	The risk of pulmonary tuberculosis after traumatic brain injury
title_full	The risk of pulmonary tuberculosis after traumatic brain injury
title_fullStr	The risk of pulmonary tuberculosis after traumatic brain injury
title_full_unstemmed	The risk of pulmonary tuberculosis after traumatic brain injury
title_sort	risk of pulmonary tuberculosis after traumatic brain injury
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/de19ac4fbabe4d448f713e7c6ffdf376
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The risk of pulmonary tuberculosis after traumatic brain injury

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