Dissociation of structural and functional connectomic coherence in glioma patients

Abstract With diffuse infiltrative glioma being increasingly recognized as a systemic brain disorder, the macroscopically apparent tumor lesion is suggested to impact on cerebral functional and structural integrity beyond the apparent lesion site. We investigated resting-state functional connectivit...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kerstin Jütten, Leon Weninger, Verena Mainz, Siegfried Gauggel, Ferdinand Binkofski, Martin Wiesmann, Dorit Merhof, Hans Clusmann, Chuh-Hyoun Na
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/de1a4873ce124cb199872575b020e056
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:de1a4873ce124cb199872575b020e056
record_format	dspace
spelling	oai:doaj.org-article:de1a4873ce124cb199872575b020e0562021-12-02T17:08:36ZDissociation of structural and functional connectomic coherence in glioma patients10.1038/s41598-021-95932-52045-2322https://doaj.org/article/de1a4873ce124cb199872575b020e0562021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95932-5https://doaj.org/toc/2045-2322Abstract With diffuse infiltrative glioma being increasingly recognized as a systemic brain disorder, the macroscopically apparent tumor lesion is suggested to impact on cerebral functional and structural integrity beyond the apparent lesion site. We investigated resting-state functional connectivity (FC) and diffusion-MRI-based structural connectivity (SC) (comprising edge-weight (EW) and fractional anisotropy (FA)) in isodehydrogenase mutated (IDHmut) and wildtype (IDHwt) patients and healthy controls. SC and FC were determined for whole-brain and the Default-Mode Network (DMN), mean intra- and interhemispheric SC and FC were compared across groups, and partial correlations were analyzed intra- and intermodally. With interhemispheric EW being reduced in both patient groups, IDHwt patients showed FA decreases in the ipsi- and contralesional hemisphere, whereas IDHmut patients revealed FA increases in the contralesional hemisphere. Healthy controls showed strong intramodal connectivity, each within the structural and functional connectome. Patients however showed a loss in structural and reductions in functional connectomic coherence, which appeared to be more pronounced in IDHwt glioma patients. Findings suggest a relative dissociation of structural and functional connectomic coherence in glioma patients at the time of diagnosis, with more structural connectomic aberrations being encountered in IDHwt glioma patients. Connectomic profiling may aid in phenotyping and monitoring prognostically differing tumor types.Kerstin JüttenLeon WeningerVerena MainzSiegfried GauggelFerdinand BinkofskiMartin WiesmannDorit MerhofHans ClusmannChuh-Hyoun NaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kerstin Jütten Leon Weninger Verena Mainz Siegfried Gauggel Ferdinand Binkofski Martin Wiesmann Dorit Merhof Hans Clusmann Chuh-Hyoun Na Dissociation of structural and functional connectomic coherence in glioma patients
description	Abstract With diffuse infiltrative glioma being increasingly recognized as a systemic brain disorder, the macroscopically apparent tumor lesion is suggested to impact on cerebral functional and structural integrity beyond the apparent lesion site. We investigated resting-state functional connectivity (FC) and diffusion-MRI-based structural connectivity (SC) (comprising edge-weight (EW) and fractional anisotropy (FA)) in isodehydrogenase mutated (IDHmut) and wildtype (IDHwt) patients and healthy controls. SC and FC were determined for whole-brain and the Default-Mode Network (DMN), mean intra- and interhemispheric SC and FC were compared across groups, and partial correlations were analyzed intra- and intermodally. With interhemispheric EW being reduced in both patient groups, IDHwt patients showed FA decreases in the ipsi- and contralesional hemisphere, whereas IDHmut patients revealed FA increases in the contralesional hemisphere. Healthy controls showed strong intramodal connectivity, each within the structural and functional connectome. Patients however showed a loss in structural and reductions in functional connectomic coherence, which appeared to be more pronounced in IDHwt glioma patients. Findings suggest a relative dissociation of structural and functional connectomic coherence in glioma patients at the time of diagnosis, with more structural connectomic aberrations being encountered in IDHwt glioma patients. Connectomic profiling may aid in phenotyping and monitoring prognostically differing tumor types.
format	article
author	Kerstin Jütten Leon Weninger Verena Mainz Siegfried Gauggel Ferdinand Binkofski Martin Wiesmann Dorit Merhof Hans Clusmann Chuh-Hyoun Na
author_facet	Kerstin Jütten Leon Weninger Verena Mainz Siegfried Gauggel Ferdinand Binkofski Martin Wiesmann Dorit Merhof Hans Clusmann Chuh-Hyoun Na
author_sort	Kerstin Jütten
title	Dissociation of structural and functional connectomic coherence in glioma patients
title_short	Dissociation of structural and functional connectomic coherence in glioma patients
title_full	Dissociation of structural and functional connectomic coherence in glioma patients
title_fullStr	Dissociation of structural and functional connectomic coherence in glioma patients
title_full_unstemmed	Dissociation of structural and functional connectomic coherence in glioma patients
title_sort	dissociation of structural and functional connectomic coherence in glioma patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/de1a4873ce124cb199872575b020e056
work_keys_str_mv	AT kerstinjutten dissociationofstructuralandfunctionalconnectomiccoherenceingliomapatients AT leonweninger dissociationofstructuralandfunctionalconnectomiccoherenceingliomapatients AT verenamainz dissociationofstructuralandfunctionalconnectomiccoherenceingliomapatients AT siegfriedgauggel dissociationofstructuralandfunctionalconnectomiccoherenceingliomapatients AT ferdinandbinkofski dissociationofstructuralandfunctionalconnectomiccoherenceingliomapatients AT martinwiesmann dissociationofstructuralandfunctionalconnectomiccoherenceingliomapatients AT doritmerhof dissociationofstructuralandfunctionalconnectomiccoherenceingliomapatients AT hansclusmann dissociationofstructuralandfunctionalconnectomiccoherenceingliomapatients AT chuhhyounna dissociationofstructuralandfunctionalconnectomiccoherenceingliomapatients
_version_	1718381587960168448

Dissociation of structural and functional connectomic coherence in glioma patients

Ejemplares similares