Molecular mechanisms of the CdnG-Cap5 antiphage defense system employing 3′,2′-cGAMP as the second messenger

Many bacterial cyclic-oligonucleotide-based antiphage signaling systems (CBASS) employ effectors with SAVED domains. Here, the authors present a biochemical and structural characterization of two such CBASS, providing mechanistic insights into bacterial antiphage defense.

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Autores principales:	Shirin Fatma, Arpita Chakravarti, Xuankun Zeng, Raven H. Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/de1e461a293446d0a6357b4dd12aedbc
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spelling	oai:doaj.org-article:de1e461a293446d0a6357b4dd12aedbc2021-11-08T11:08:47ZMolecular mechanisms of the CdnG-Cap5 antiphage defense system employing 3′,2′-cGAMP as the second messenger10.1038/s41467-021-26738-22041-1723https://doaj.org/article/de1e461a293446d0a6357b4dd12aedbc2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26738-2https://doaj.org/toc/2041-1723Many bacterial cyclic-oligonucleotide-based antiphage signaling systems (CBASS) employ effectors with SAVED domains. Here, the authors present a biochemical and structural characterization of two such CBASS, providing mechanistic insights into bacterial antiphage defense.Shirin FatmaArpita ChakravartiXuankun ZengRaven H. HuangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shirin Fatma Arpita Chakravarti Xuankun Zeng Raven H. Huang Molecular mechanisms of the CdnG-Cap5 antiphage defense system employing 3′,2′-cGAMP as the second messenger
description	Many bacterial cyclic-oligonucleotide-based antiphage signaling systems (CBASS) employ effectors with SAVED domains. Here, the authors present a biochemical and structural characterization of two such CBASS, providing mechanistic insights into bacterial antiphage defense.
format	article
author	Shirin Fatma Arpita Chakravarti Xuankun Zeng Raven H. Huang
author_facet	Shirin Fatma Arpita Chakravarti Xuankun Zeng Raven H. Huang
author_sort	Shirin Fatma
title	Molecular mechanisms of the CdnG-Cap5 antiphage defense system employing 3′,2′-cGAMP as the second messenger
title_short	Molecular mechanisms of the CdnG-Cap5 antiphage defense system employing 3′,2′-cGAMP as the second messenger
title_full	Molecular mechanisms of the CdnG-Cap5 antiphage defense system employing 3′,2′-cGAMP as the second messenger
title_fullStr	Molecular mechanisms of the CdnG-Cap5 antiphage defense system employing 3′,2′-cGAMP as the second messenger
title_full_unstemmed	Molecular mechanisms of the CdnG-Cap5 antiphage defense system employing 3′,2′-cGAMP as the second messenger
title_sort	molecular mechanisms of the cdng-cap5 antiphage defense system employing 3′,2′-cgamp as the second messenger
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/de1e461a293446d0a6357b4dd12aedbc
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Molecular mechanisms of the CdnG-Cap5 antiphage defense system employing 3′,2′-cGAMP as the second messenger

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