Regional distribution of computed tomography attenuation across the lumbar endplate

The vertebral endplate forms a structural boundary between intervertebral disc and the trabecular bone of the vertebral body. As a mechanical interface between the stiff bone and resilient disc, the endplate is the weakest portion of the vertebral-disc complex and is predisposed to mechanical failur...

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Autores principales:	Kazuyuki Segami, Alejandro A. Espinoza Orías, Hiroe Miyamoto, Koji Kanzaki, Howard S. An, Nozomu Inoue
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/de1f1afc6d034828b907c262f134daac
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spelling	oai:doaj.org-article:de1f1afc6d034828b907c262f134daac2021-11-04T06:49:41ZRegional distribution of computed tomography attenuation across the lumbar endplate1932-6203https://doaj.org/article/de1f1afc6d034828b907c262f134daac2021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8550599/?tool=EBIhttps://doaj.org/toc/1932-6203The vertebral endplate forms a structural boundary between intervertebral disc and the trabecular bone of the vertebral body. As a mechanical interface between the stiff bone and resilient disc, the endplate is the weakest portion of the vertebral-disc complex and is predisposed to mechanical failure. However, the literature concerning the bone mineral density (BMD) distribution within the spinal endplate is comparatively sparse. The objective of this study is to investigate the three-dimensional (3D) distribution of computed tomography (CT) attenuation across the lumbosacral endplate measured in Hounsfield Units (HU). A total of 308 endplates from 28 cadaveric fresh-frozen lumbosacral spines were used in this study. Each spine was CT-scanned and the resulting DICOM data was used to obtain HU values of the bone endplate. Each individual endplate surface was subdivided into five clinically-relevant topographic zones. Attenuation was analyzed by spinal levels, sites (superior or inferior endplate) and endplate region. The highest HU values were found at the S1 endplate. Comparisons between the superior and inferior endplates showed the HU values in inferior endplates were significantly higher than those in the superior endplates within the same vertebra and the HU values in endplates cranial to the disc were significantly higher than those in the endplates caudal to the disc within the same disc. Attenuation in the peripheral region was significantly higher than in the central region by 32.5%. Regional comparison within the peripheral region showed the HU values in the posterior region were significantly higher than those in the anterior region and the HU values in the left region were significantly higher than those in the right region. This study provided detailed data on the regional HU distribution across the lumbosacral endplate, which can be useful to understand causes of some endplate lesions, such as fracture, and also to design interbody instrumentation.Kazuyuki SegamiAlejandro A. Espinoza OríasHiroe MiyamotoKoji KanzakiHoward S. AnNozomu InouePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kazuyuki Segami Alejandro A. Espinoza Orías Hiroe Miyamoto Koji Kanzaki Howard S. An Nozomu Inoue Regional distribution of computed tomography attenuation across the lumbar endplate
description	The vertebral endplate forms a structural boundary between intervertebral disc and the trabecular bone of the vertebral body. As a mechanical interface between the stiff bone and resilient disc, the endplate is the weakest portion of the vertebral-disc complex and is predisposed to mechanical failure. However, the literature concerning the bone mineral density (BMD) distribution within the spinal endplate is comparatively sparse. The objective of this study is to investigate the three-dimensional (3D) distribution of computed tomography (CT) attenuation across the lumbosacral endplate measured in Hounsfield Units (HU). A total of 308 endplates from 28 cadaveric fresh-frozen lumbosacral spines were used in this study. Each spine was CT-scanned and the resulting DICOM data was used to obtain HU values of the bone endplate. Each individual endplate surface was subdivided into five clinically-relevant topographic zones. Attenuation was analyzed by spinal levels, sites (superior or inferior endplate) and endplate region. The highest HU values were found at the S1 endplate. Comparisons between the superior and inferior endplates showed the HU values in inferior endplates were significantly higher than those in the superior endplates within the same vertebra and the HU values in endplates cranial to the disc were significantly higher than those in the endplates caudal to the disc within the same disc. Attenuation in the peripheral region was significantly higher than in the central region by 32.5%. Regional comparison within the peripheral region showed the HU values in the posterior region were significantly higher than those in the anterior region and the HU values in the left region were significantly higher than those in the right region. This study provided detailed data on the regional HU distribution across the lumbosacral endplate, which can be useful to understand causes of some endplate lesions, such as fracture, and also to design interbody instrumentation.
format	article
author	Kazuyuki Segami Alejandro A. Espinoza Orías Hiroe Miyamoto Koji Kanzaki Howard S. An Nozomu Inoue
author_facet	Kazuyuki Segami Alejandro A. Espinoza Orías Hiroe Miyamoto Koji Kanzaki Howard S. An Nozomu Inoue
author_sort	Kazuyuki Segami
title	Regional distribution of computed tomography attenuation across the lumbar endplate
title_short	Regional distribution of computed tomography attenuation across the lumbar endplate
title_full	Regional distribution of computed tomography attenuation across the lumbar endplate
title_fullStr	Regional distribution of computed tomography attenuation across the lumbar endplate
title_full_unstemmed	Regional distribution of computed tomography attenuation across the lumbar endplate
title_sort	regional distribution of computed tomography attenuation across the lumbar endplate
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/de1f1afc6d034828b907c262f134daac
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Regional distribution of computed tomography attenuation across the lumbar endplate

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