Oligodendrocytic Na+-K+-Cl– co-transporter 1 activity facilitates axonal conduction and restores plasticity in the adult mouse brain

Brain plasticity declines with age. Here, the authors show that NKCC1 regulates oligodendrocyte activity, facilitating neuronal plasticity during juvenile. Inducing activation of oligodendrocytic NKCC1 results in restoration of neuronal plasticity in the adult mouse brain.

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Autores principales:	Yoshihiko Yamazaki, Yoshifumi Abe, Satoshi Fujii, Kenji F. Tanaka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/de1f9e39c2ca46f8845c1c60175443f6
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spelling	oai:doaj.org-article:de1f9e39c2ca46f8845c1c60175443f62021-12-02T15:09:09ZOligodendrocytic Na+-K+-Cl– co-transporter 1 activity facilitates axonal conduction and restores plasticity in the adult mouse brain10.1038/s41467-021-25488-52041-1723https://doaj.org/article/de1f9e39c2ca46f8845c1c60175443f62021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25488-5https://doaj.org/toc/2041-1723Brain plasticity declines with age. Here, the authors show that NKCC1 regulates oligodendrocyte activity, facilitating neuronal plasticity during juvenile. Inducing activation of oligodendrocytic NKCC1 results in restoration of neuronal plasticity in the adult mouse brain.Yoshihiko YamazakiYoshifumi AbeSatoshi FujiiKenji F. TanakaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yoshihiko Yamazaki Yoshifumi Abe Satoshi Fujii Kenji F. Tanaka Oligodendrocytic Na+-K+-Cl– co-transporter 1 activity facilitates axonal conduction and restores plasticity in the adult mouse brain
description	Brain plasticity declines with age. Here, the authors show that NKCC1 regulates oligodendrocyte activity, facilitating neuronal plasticity during juvenile. Inducing activation of oligodendrocytic NKCC1 results in restoration of neuronal plasticity in the adult mouse brain.
format	article
author	Yoshihiko Yamazaki Yoshifumi Abe Satoshi Fujii Kenji F. Tanaka
author_facet	Yoshihiko Yamazaki Yoshifumi Abe Satoshi Fujii Kenji F. Tanaka
author_sort	Yoshihiko Yamazaki
title	Oligodendrocytic Na+-K+-Cl– co-transporter 1 activity facilitates axonal conduction and restores plasticity in the adult mouse brain
title_short	Oligodendrocytic Na+-K+-Cl– co-transporter 1 activity facilitates axonal conduction and restores plasticity in the adult mouse brain
title_full	Oligodendrocytic Na+-K+-Cl– co-transporter 1 activity facilitates axonal conduction and restores plasticity in the adult mouse brain
title_fullStr	Oligodendrocytic Na+-K+-Cl– co-transporter 1 activity facilitates axonal conduction and restores plasticity in the adult mouse brain
title_full_unstemmed	Oligodendrocytic Na+-K+-Cl– co-transporter 1 activity facilitates axonal conduction and restores plasticity in the adult mouse brain
title_sort	oligodendrocytic na+-k+-cl– co-transporter 1 activity facilitates axonal conduction and restores plasticity in the adult mouse brain
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/de1f9e39c2ca46f8845c1c60175443f6
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Oligodendrocytic Na+-K+-Cl– co-transporter 1 activity facilitates axonal conduction and restores plasticity in the adult mouse brain

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