Unusual presentations of a severe type 2 leprosy reaction mimicking sepsis induced by helminth infection.

We describe an unusual case of type 2 leprosy reaction (T2R) with septic shock-like features induced by helminth infection in a 31-year-old Moluccan male patient with a history of completed treatment of WHO multidrug therapy (MDT)-multibacillary (MB) regimen 2 years before admission. During the cour...

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Autores principales:	Sri Linuwih Menaldi, Anastasia Asylia Dinakrisma, Hok Bing Thio, Iris Rengganis, Salma Oktaria
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/de20545e53b8461596653a3fcc5f2114
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spelling	oai:doaj.org-article:de20545e53b8461596653a3fcc5f21142021-11-25T06:33:27ZUnusual presentations of a severe type 2 leprosy reaction mimicking sepsis induced by helminth infection.1935-27271935-273510.1371/journal.pntd.0009453https://doaj.org/article/de20545e53b8461596653a3fcc5f21142021-07-01T00:00:00Zhttps://doi.org/10.1371/journal.pntd.0009453https://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735We describe an unusual case of type 2 leprosy reaction (T2R) with septic shock-like features induced by helminth infection in a 31-year-old Moluccan male patient with a history of completed treatment of WHO multidrug therapy (MDT)-multibacillary (MB) regimen 2 years before admission. During the course of illness, the patient had numerous complications, including septic shock, anemia, and disseminated intravascular coagulation (DIC). Nevertheless, antibiotic therapies failed to give significant results, and the source of infection could not be identified. Helminth infection was subsequently revealed by endoscopic examination followed by parasitological culture. Resolution of symptoms and normal level of organ function-specific markers were resolved within 3 days following anthelmintic treatment. This report demonstrated the challenge in the diagnosis and treatment of severe T2R. Given that helminth infections may trigger severe T2R that mimics septic shock, health professionals need to be aware of this clinical presentation, especially in endemic regions of both diseases.Sri Linuwih MenaldiAnastasia Asylia DinakrismaHok Bing ThioIris RengganisSalma OktariaPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 15, Iss 7, p e0009453 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Sri Linuwih Menaldi Anastasia Asylia Dinakrisma Hok Bing Thio Iris Rengganis Salma Oktaria Unusual presentations of a severe type 2 leprosy reaction mimicking sepsis induced by helminth infection.
description	We describe an unusual case of type 2 leprosy reaction (T2R) with septic shock-like features induced by helminth infection in a 31-year-old Moluccan male patient with a history of completed treatment of WHO multidrug therapy (MDT)-multibacillary (MB) regimen 2 years before admission. During the course of illness, the patient had numerous complications, including septic shock, anemia, and disseminated intravascular coagulation (DIC). Nevertheless, antibiotic therapies failed to give significant results, and the source of infection could not be identified. Helminth infection was subsequently revealed by endoscopic examination followed by parasitological culture. Resolution of symptoms and normal level of organ function-specific markers were resolved within 3 days following anthelmintic treatment. This report demonstrated the challenge in the diagnosis and treatment of severe T2R. Given that helminth infections may trigger severe T2R that mimics septic shock, health professionals need to be aware of this clinical presentation, especially in endemic regions of both diseases.
format	article
author	Sri Linuwih Menaldi Anastasia Asylia Dinakrisma Hok Bing Thio Iris Rengganis Salma Oktaria
author_facet	Sri Linuwih Menaldi Anastasia Asylia Dinakrisma Hok Bing Thio Iris Rengganis Salma Oktaria
author_sort	Sri Linuwih Menaldi
title	Unusual presentations of a severe type 2 leprosy reaction mimicking sepsis induced by helminth infection.
title_short	Unusual presentations of a severe type 2 leprosy reaction mimicking sepsis induced by helminth infection.
title_full	Unusual presentations of a severe type 2 leprosy reaction mimicking sepsis induced by helminth infection.
title_fullStr	Unusual presentations of a severe type 2 leprosy reaction mimicking sepsis induced by helminth infection.
title_full_unstemmed	Unusual presentations of a severe type 2 leprosy reaction mimicking sepsis induced by helminth infection.
title_sort	unusual presentations of a severe type 2 leprosy reaction mimicking sepsis induced by helminth infection.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/de20545e53b8461596653a3fcc5f2114
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Unusual presentations of a severe type 2 leprosy reaction mimicking sepsis induced by helminth infection.

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