VCAM-1 Is Upregulated in Uranium Miners Compared to Other Miners

The United States has a rich history of mining including uranium (U)-mining, coal mining, and other metal mining. Cardiovascular diseases (CVD) are largely understudied in miners and recent literature suggests that when compared to non-U miners, U-miners are more likely to report CVD. However, the m...

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Autores principales:	Nour A. Ass’ad, Xin Shore, Orrin Myers, Alexandra R. Camacho, Quiteria Jacquez, Charles Pollard, Linda S. Cook, Shuguang Leng, Kimberly Page, Akshay Sood, Katherine E. Zychowski
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	VCAM-1 inflammation cardiovascular mining Science Q
Acceso en línea:	https://doaj.org/article/de21b3ea36fb4e0fb6782ca18f3e12c3
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id	oai:doaj.org-article:de21b3ea36fb4e0fb6782ca18f3e12c3
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spelling	oai:doaj.org-article:de21b3ea36fb4e0fb6782ca18f3e12c32021-11-25T18:11:20ZVCAM-1 Is Upregulated in Uranium Miners Compared to Other Miners10.3390/life111112232075-1729https://doaj.org/article/de21b3ea36fb4e0fb6782ca18f3e12c32021-11-01T00:00:00Zhttps://www.mdpi.com/2075-1729/11/11/1223https://doaj.org/toc/2075-1729The United States has a rich history of mining including uranium (U)-mining, coal mining, and other metal mining. Cardiovascular diseases (CVD) are largely understudied in miners and recent literature suggests that when compared to non-U miners, U-miners are more likely to report CVD. However, the molecular basis for this phenomenon is currently unknown. In this pilot study, a New Mexico (NM)-based occupational cohort of current and former miners (<i>n</i> = 44) were recruited via a mobile screening clinic for miners. Serum- and endothelial-based endpoints were used to assess circulating inflammatory potential relevant to CVD. Non-U miners reported significantly fewer pack years of smoking than U-miners. Circulating biomarkers of interest revealed that U-miners had significantly greater serum amyloid A (SAA), soluble intercellular adhesion molecule 1 (ICAM-1, ng/mL), soluble vascular cell adhesion molecule 1 (VCAM-1, ng/mL), and VCAM-1 mRNA expression, as determined by the serum cumulative inflammatory potential (SCIP) assay, an endothelial-based assay. Even after adjusting for various covariates, including age, multivariable analysis determined that U-miners had significantly upregulated VCAM-1 mRNA. In conclusion, VCAM-1 may be an important biomarker and possible contributor of CVD in U-miners. Further research to explore this mechanism may be warranted.Nour A. Ass’adXin ShoreOrrin MyersAlexandra R. CamachoQuiteria JacquezCharles PollardLinda S. CookShuguang LengKimberly PageAkshay SoodKatherine E. ZychowskiMDPI AGarticleVCAM-1inflammationcardiovascularminingScienceQENLife, Vol 11, Iss 1223, p 1223 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	VCAM-1 inflammation cardiovascular mining Science Q
spellingShingle	VCAM-1 inflammation cardiovascular mining Science Q Nour A. Ass’ad Xin Shore Orrin Myers Alexandra R. Camacho Quiteria Jacquez Charles Pollard Linda S. Cook Shuguang Leng Kimberly Page Akshay Sood Katherine E. Zychowski VCAM-1 Is Upregulated in Uranium Miners Compared to Other Miners
description	The United States has a rich history of mining including uranium (U)-mining, coal mining, and other metal mining. Cardiovascular diseases (CVD) are largely understudied in miners and recent literature suggests that when compared to non-U miners, U-miners are more likely to report CVD. However, the molecular basis for this phenomenon is currently unknown. In this pilot study, a New Mexico (NM)-based occupational cohort of current and former miners (<i>n</i> = 44) were recruited via a mobile screening clinic for miners. Serum- and endothelial-based endpoints were used to assess circulating inflammatory potential relevant to CVD. Non-U miners reported significantly fewer pack years of smoking than U-miners. Circulating biomarkers of interest revealed that U-miners had significantly greater serum amyloid A (SAA), soluble intercellular adhesion molecule 1 (ICAM-1, ng/mL), soluble vascular cell adhesion molecule 1 (VCAM-1, ng/mL), and VCAM-1 mRNA expression, as determined by the serum cumulative inflammatory potential (SCIP) assay, an endothelial-based assay. Even after adjusting for various covariates, including age, multivariable analysis determined that U-miners had significantly upregulated VCAM-1 mRNA. In conclusion, VCAM-1 may be an important biomarker and possible contributor of CVD in U-miners. Further research to explore this mechanism may be warranted.
format	article
author	Nour A. Ass’ad Xin Shore Orrin Myers Alexandra R. Camacho Quiteria Jacquez Charles Pollard Linda S. Cook Shuguang Leng Kimberly Page Akshay Sood Katherine E. Zychowski
author_facet	Nour A. Ass’ad Xin Shore Orrin Myers Alexandra R. Camacho Quiteria Jacquez Charles Pollard Linda S. Cook Shuguang Leng Kimberly Page Akshay Sood Katherine E. Zychowski
author_sort	Nour A. Ass’ad
title	VCAM-1 Is Upregulated in Uranium Miners Compared to Other Miners
title_short	VCAM-1 Is Upregulated in Uranium Miners Compared to Other Miners
title_full	VCAM-1 Is Upregulated in Uranium Miners Compared to Other Miners
title_fullStr	VCAM-1 Is Upregulated in Uranium Miners Compared to Other Miners
title_full_unstemmed	VCAM-1 Is Upregulated in Uranium Miners Compared to Other Miners
title_sort	vcam-1 is upregulated in uranium miners compared to other miners
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/de21b3ea36fb4e0fb6782ca18f3e12c3
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VCAM-1 Is Upregulated in Uranium Miners Compared to Other Miners

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