Mucus Is a Key Factor in <named-content content-type="genus-species">Neisseria meningitidis</named-content> Commensalism

ABSTRACT The work presented by Audry et al. (M. Audry, C. Robbe-Masselot, J.-P. Barnier, B. Gachet, et al., mSphere 4:e00494-19, 2019, https://doi.org/10.1128/mSphere.00494-19) gives new insight into the interactions of Neisseria meningitidis and the human nasopharynx. Using an air interface tissue...

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Autores principales:	Melanie M. Callaghan, Joseph P. Dillard
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2019
Materias:	Neisseria meningitidis commensal mucus Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/de25a135886a47bcbaf1eebe741f3b60
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spelling	oai:doaj.org-article:de25a135886a47bcbaf1eebe741f3b602021-11-15T15:22:24ZMucus Is a Key Factor in <named-content content-type="genus-species">Neisseria meningitidis</named-content> Commensalism10.1128/mSphere.00777-192379-5042https://doaj.org/article/de25a135886a47bcbaf1eebe741f3b602019-12-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00777-19https://doaj.org/toc/2379-5042ABSTRACT The work presented by Audry et al. (M. Audry, C. Robbe-Masselot, J.-P. Barnier, B. Gachet, et al., mSphere 4:e00494-19, 2019, https://doi.org/10.1128/mSphere.00494-19) gives new insight into the interactions of Neisseria meningitidis and the human nasopharynx. Using an air interface tissue culture model of a polarized, mucus-secreting epithelium, Audry et al. demonstrate that N. meningitidis bacteria do not commonly invade epithelial cells. Rather, they are trapped in the mucus layer, where they are protected from dessication. In this model, meningicocci fail to elicit a pro-inflammatory immune response and show growth effects in response to another nasopharyngeal colonizer, Streptococcus mitis. These findings prompt new questions about pathobiont behaviors, the role of mucus in bacterium-host interactions, and modeling human infection.Melanie M. CallaghanJoseph P. DillardAmerican Society for MicrobiologyarticleNeisseria meningitidiscommensalmucusMicrobiologyQR1-502ENmSphere, Vol 4, Iss 6 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neisseria meningitidis commensal mucus Microbiology QR1-502
spellingShingle	Neisseria meningitidis commensal mucus Microbiology QR1-502 Melanie M. Callaghan Joseph P. Dillard Mucus Is a Key Factor in <named-content content-type="genus-species">Neisseria meningitidis</named-content> Commensalism
description	ABSTRACT The work presented by Audry et al. (M. Audry, C. Robbe-Masselot, J.-P. Barnier, B. Gachet, et al., mSphere 4:e00494-19, 2019, https://doi.org/10.1128/mSphere.00494-19) gives new insight into the interactions of Neisseria meningitidis and the human nasopharynx. Using an air interface tissue culture model of a polarized, mucus-secreting epithelium, Audry et al. demonstrate that N. meningitidis bacteria do not commonly invade epithelial cells. Rather, they are trapped in the mucus layer, where they are protected from dessication. In this model, meningicocci fail to elicit a pro-inflammatory immune response and show growth effects in response to another nasopharyngeal colonizer, Streptococcus mitis. These findings prompt new questions about pathobiont behaviors, the role of mucus in bacterium-host interactions, and modeling human infection.
format	article
author	Melanie M. Callaghan Joseph P. Dillard
author_facet	Melanie M. Callaghan Joseph P. Dillard
author_sort	Melanie M. Callaghan
title	Mucus Is a Key Factor in <named-content content-type="genus-species">Neisseria meningitidis</named-content> Commensalism
title_short	Mucus Is a Key Factor in <named-content content-type="genus-species">Neisseria meningitidis</named-content> Commensalism
title_full	Mucus Is a Key Factor in <named-content content-type="genus-species">Neisseria meningitidis</named-content> Commensalism
title_fullStr	Mucus Is a Key Factor in <named-content content-type="genus-species">Neisseria meningitidis</named-content> Commensalism
title_full_unstemmed	Mucus Is a Key Factor in <named-content content-type="genus-species">Neisseria meningitidis</named-content> Commensalism
title_sort	mucus is a key factor in <named-content content-type="genus-species">neisseria meningitidis</named-content> commensalism
publisher	American Society for Microbiology
publishDate	2019
url	https://doaj.org/article/de25a135886a47bcbaf1eebe741f3b60
work_keys_str_mv	AT melaniemcallaghan mucusisakeyfactorinnamedcontentcontenttypegenusspeciesneisseriameningitidisnamedcontentcommensalism AT josephpdillard mucusisakeyfactorinnamedcontentcontenttypegenusspeciesneisseriameningitidisnamedcontentcommensalism
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Mucus Is a Key Factor in <named-content content-type="genus-species">Neisseria meningitidis</named-content> Commensalism

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