Broad cross protection by recombinant live attenuated influenza H3N2 seasonal virus expressing conserved M2 extracellular domain in a chimeric hemagglutinin
Abstract Hemagglutinin (HA)-based current vaccines provide suboptimum cross protection. Influenza A virus contains an ion channel protein M2 conserved extracellular domain (M2e), a target for developing universal vaccines. Here we generated reassortant influenza virus rgH3N2 4xM2e virus (HA and NA f...
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Autores principales: | Bo Ryoung Park, Ki-Hye Kim, Tatiana Kotomina, Min-Chul Kim, Young-Man Kwon, Subbiah Jeeva, Yu-Jin Jung, Noopur Bhatnagar, Irina Isakova-Sivak, Daria Mezhenskaya, Larisa Rudenko, Bao-Zhong Wang, Sang-Moo Kang |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
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Materias: | |
Acceso en línea: | https://doaj.org/article/de27ac60c5a6402b8c6c3bb5e7a6fea3 |
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