microRNAs in human brucellosis: A promising therapeutic approach and biomarker for diagnosis and treatment

Abstract Introduction Human brucellosis is a zoonotic bacterial disease with up to 500,000 new cases each year. The major evasion mechanisms from the host immune system by Brucella are restraint of complement pathway and Toll‐like receptors signaling pathways, interference with efficient antigen pre...

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Autores principales:	Sima Kazemi, Rasoul Mirzaei, Mohammad Sholeh, Sajad Karampoor, Fariba Keramat, Massoud Saidijam, Mohammad Yousef Alikhani
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	biomarker brucellosis immunopathogenesis microRNAs therapeutic targets Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/de310240b83a42ef9ef838a9790b8cae
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spelling	oai:doaj.org-article:de310240b83a42ef9ef838a9790b8cae2021-11-12T19:57:14ZmicroRNAs in human brucellosis: A promising therapeutic approach and biomarker for diagnosis and treatment2050-452710.1002/iid3.519https://doaj.org/article/de310240b83a42ef9ef838a9790b8cae2021-12-01T00:00:00Zhttps://doi.org/10.1002/iid3.519https://doaj.org/toc/2050-4527Abstract Introduction Human brucellosis is a zoonotic bacterial disease with up to 500,000 new cases each year. The major evasion mechanisms from the host immune system by Brucella are restraint of complement pathway and Toll‐like receptors signaling pathways, interference with efficient antigen presentation to CD4‐positive T lymphocytes, selective subversion of autophagy pathways, inhibition of dendritic cell stimulation, inhibition of autophagolysosomal fusion, and macrophage apoptosis. Many molecular and cellular pathways contribute to brucellosis that microRNAs have a vital function in the immunopathogenesis of this disease. In this regard, these molecules apply for their roles by modulating various events like inflammatory reactions and immune defense. Recently, in the case of immunity to human brucellosis, it has been shown that microRNAs play an important role in immunity against these bacteria. Methods and Results In this study, we tried to review the immune defense and immunopathogenesis of Brucella infection and highlight the current knowledge of the microRNAs in infected cells by Brucella pathogens. The recent findings suggest that the regulation of microRNAs expression is impaired during brucellosis infection, which may contribute to disease progression or inhibition by modulating immune responses against this pathogen. Conclusions The interplay between miRNAs and Brucella pathogens and the underlying process required comprehensive examination to unravel the novel therapeutic or diagnostic approaches.Sima KazemiRasoul MirzaeiMohammad SholehSajad KarampoorFariba KeramatMassoud SaidijamMohammad Yousef AlikhaniWileyarticlebiomarkerbrucellosisimmunopathogenesismicroRNAstherapeutic targetsImmunologic diseases. AllergyRC581-607ENImmunity, Inflammation and Disease, Vol 9, Iss 4, Pp 1209-1218 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	biomarker brucellosis immunopathogenesis microRNAs therapeutic targets Immunologic diseases. Allergy RC581-607
spellingShingle	biomarker brucellosis immunopathogenesis microRNAs therapeutic targets Immunologic diseases. Allergy RC581-607 Sima Kazemi Rasoul Mirzaei Mohammad Sholeh Sajad Karampoor Fariba Keramat Massoud Saidijam Mohammad Yousef Alikhani microRNAs in human brucellosis: A promising therapeutic approach and biomarker for diagnosis and treatment
description	Abstract Introduction Human brucellosis is a zoonotic bacterial disease with up to 500,000 new cases each year. The major evasion mechanisms from the host immune system by Brucella are restraint of complement pathway and Toll‐like receptors signaling pathways, interference with efficient antigen presentation to CD4‐positive T lymphocytes, selective subversion of autophagy pathways, inhibition of dendritic cell stimulation, inhibition of autophagolysosomal fusion, and macrophage apoptosis. Many molecular and cellular pathways contribute to brucellosis that microRNAs have a vital function in the immunopathogenesis of this disease. In this regard, these molecules apply for their roles by modulating various events like inflammatory reactions and immune defense. Recently, in the case of immunity to human brucellosis, it has been shown that microRNAs play an important role in immunity against these bacteria. Methods and Results In this study, we tried to review the immune defense and immunopathogenesis of Brucella infection and highlight the current knowledge of the microRNAs in infected cells by Brucella pathogens. The recent findings suggest that the regulation of microRNAs expression is impaired during brucellosis infection, which may contribute to disease progression or inhibition by modulating immune responses against this pathogen. Conclusions The interplay between miRNAs and Brucella pathogens and the underlying process required comprehensive examination to unravel the novel therapeutic or diagnostic approaches.
format	article
author	Sima Kazemi Rasoul Mirzaei Mohammad Sholeh Sajad Karampoor Fariba Keramat Massoud Saidijam Mohammad Yousef Alikhani
author_facet	Sima Kazemi Rasoul Mirzaei Mohammad Sholeh Sajad Karampoor Fariba Keramat Massoud Saidijam Mohammad Yousef Alikhani
author_sort	Sima Kazemi
title	microRNAs in human brucellosis: A promising therapeutic approach and biomarker for diagnosis and treatment
title_short	microRNAs in human brucellosis: A promising therapeutic approach and biomarker for diagnosis and treatment
title_full	microRNAs in human brucellosis: A promising therapeutic approach and biomarker for diagnosis and treatment
title_fullStr	microRNAs in human brucellosis: A promising therapeutic approach and biomarker for diagnosis and treatment
title_full_unstemmed	microRNAs in human brucellosis: A promising therapeutic approach and biomarker for diagnosis and treatment
title_sort	micrornas in human brucellosis: a promising therapeutic approach and biomarker for diagnosis and treatment
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/de310240b83a42ef9ef838a9790b8cae
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microRNAs in human brucellosis: A promising therapeutic approach and biomarker for diagnosis and treatment

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