Maternal aryl hydrocarbon receptor activation protects newborns against necrotizing enterocolitis

Necrotizing enterocolitis (NEC) is a disease of prematurity requiring Toll-like receptor 4 (TLR4) activation on the gut epithelium. Here the authors show that the aryl hydrocarbon receptor (AHR) mediates NEC pathogenesis via effects on TLR4, and that supplementing the diet with AHR ligands during pr...

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Autores principales:	Peng Lu, Yukihiro Yamaguchi, William B. Fulton, Sanxia Wang, Qinjie Zhou, Hongpeng Jia, Mark L. Kovler, Andres Gonzalez Salazar, Maame Sampah, Thomas Prindle, Peter Wipf, Chhinder P. Sodhi, David J. Hackam
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/de31495f0c8949b19339b71ff987a273
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spelling	oai:doaj.org-article:de31495f0c8949b19339b71ff987a2732021-12-02T14:21:24ZMaternal aryl hydrocarbon receptor activation protects newborns against necrotizing enterocolitis10.1038/s41467-021-21356-42041-1723https://doaj.org/article/de31495f0c8949b19339b71ff987a2732021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21356-4https://doaj.org/toc/2041-1723Necrotizing enterocolitis (NEC) is a disease of prematurity requiring Toll-like receptor 4 (TLR4) activation on the gut epithelium. Here the authors show that the aryl hydrocarbon receptor (AHR) mediates NEC pathogenesis via effects on TLR4, and that supplementing the diet with AHR ligands during pregnancy or postnatally prevents NEC.Peng LuYukihiro YamaguchiWilliam B. FultonSanxia WangQinjie ZhouHongpeng JiaMark L. KovlerAndres Gonzalez SalazarMaame SampahThomas PrindlePeter WipfChhinder P. SodhiDavid J. HackamNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Peng Lu Yukihiro Yamaguchi William B. Fulton Sanxia Wang Qinjie Zhou Hongpeng Jia Mark L. Kovler Andres Gonzalez Salazar Maame Sampah Thomas Prindle Peter Wipf Chhinder P. Sodhi David J. Hackam Maternal aryl hydrocarbon receptor activation protects newborns against necrotizing enterocolitis
description	Necrotizing enterocolitis (NEC) is a disease of prematurity requiring Toll-like receptor 4 (TLR4) activation on the gut epithelium. Here the authors show that the aryl hydrocarbon receptor (AHR) mediates NEC pathogenesis via effects on TLR4, and that supplementing the diet with AHR ligands during pregnancy or postnatally prevents NEC.
format	article
author	Peng Lu Yukihiro Yamaguchi William B. Fulton Sanxia Wang Qinjie Zhou Hongpeng Jia Mark L. Kovler Andres Gonzalez Salazar Maame Sampah Thomas Prindle Peter Wipf Chhinder P. Sodhi David J. Hackam
author_facet	Peng Lu Yukihiro Yamaguchi William B. Fulton Sanxia Wang Qinjie Zhou Hongpeng Jia Mark L. Kovler Andres Gonzalez Salazar Maame Sampah Thomas Prindle Peter Wipf Chhinder P. Sodhi David J. Hackam
author_sort	Peng Lu
title	Maternal aryl hydrocarbon receptor activation protects newborns against necrotizing enterocolitis
title_short	Maternal aryl hydrocarbon receptor activation protects newborns against necrotizing enterocolitis
title_full	Maternal aryl hydrocarbon receptor activation protects newborns against necrotizing enterocolitis
title_fullStr	Maternal aryl hydrocarbon receptor activation protects newborns against necrotizing enterocolitis
title_full_unstemmed	Maternal aryl hydrocarbon receptor activation protects newborns against necrotizing enterocolitis
title_sort	maternal aryl hydrocarbon receptor activation protects newborns against necrotizing enterocolitis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/de31495f0c8949b19339b71ff987a273
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Maternal aryl hydrocarbon receptor activation protects newborns against necrotizing enterocolitis

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