FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis
Uncoupling protein-1 (UCP1) plays a central role in energy dissipation in brown adipose tissue. Here the authors show that FGF6 and FGF9 induce UCP1 expression in adipocytes and preadipocytes, via modulation of a transcriptional network that is dissociated from brown adipogenesis.
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Nature Portfolio
2020
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oai:doaj.org-article:de377e337a5a402280aaea762fc97cbe2021-12-02T14:40:52ZFGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis10.1038/s41467-020-15055-92041-1723https://doaj.org/article/de377e337a5a402280aaea762fc97cbe2020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15055-9https://doaj.org/toc/2041-1723Uncoupling protein-1 (UCP1) plays a central role in energy dissipation in brown adipose tissue. Here the authors show that FGF6 and FGF9 induce UCP1 expression in adipocytes and preadipocytes, via modulation of a transcriptional network that is dissociated from brown adipogenesis.Farnaz ShamsiRuidan XueTian Lian HuangMorten LundhYang LiuLuiz O. LeiriaMatthew D. LynesElena KempfChih-Hao WangSatoru SugimotoPasquale NigroKathrin LandgrafTim SchulzYiming LiBrice EmanuelliSrinivas KothakotaLewis T. WilliamsNiels JessenSteen Bønløkke PedersenYvonne BöttcherMatthias BlüherAntje KörnerLaurie J. GoodyearMoosa MohammadiC. Ronald KahnYu-Hua TsengNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Farnaz Shamsi Ruidan Xue Tian Lian Huang Morten Lundh Yang Liu Luiz O. Leiria Matthew D. Lynes Elena Kempf Chih-Hao Wang Satoru Sugimoto Pasquale Nigro Kathrin Landgraf Tim Schulz Yiming Li Brice Emanuelli Srinivas Kothakota Lewis T. Williams Niels Jessen Steen Bønløkke Pedersen Yvonne Böttcher Matthias Blüher Antje Körner Laurie J. Goodyear Moosa Mohammadi C. Ronald Kahn Yu-Hua Tseng FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis |
| description |
Uncoupling protein-1 (UCP1) plays a central role in energy dissipation in brown adipose tissue. Here the authors show that FGF6 and FGF9 induce UCP1 expression in adipocytes and preadipocytes, via modulation of a transcriptional network that is dissociated from brown adipogenesis. |
| format |
article |
| author |
Farnaz Shamsi Ruidan Xue Tian Lian Huang Morten Lundh Yang Liu Luiz O. Leiria Matthew D. Lynes Elena Kempf Chih-Hao Wang Satoru Sugimoto Pasquale Nigro Kathrin Landgraf Tim Schulz Yiming Li Brice Emanuelli Srinivas Kothakota Lewis T. Williams Niels Jessen Steen Bønløkke Pedersen Yvonne Böttcher Matthias Blüher Antje Körner Laurie J. Goodyear Moosa Mohammadi C. Ronald Kahn Yu-Hua Tseng |
| author_facet |
Farnaz Shamsi Ruidan Xue Tian Lian Huang Morten Lundh Yang Liu Luiz O. Leiria Matthew D. Lynes Elena Kempf Chih-Hao Wang Satoru Sugimoto Pasquale Nigro Kathrin Landgraf Tim Schulz Yiming Li Brice Emanuelli Srinivas Kothakota Lewis T. Williams Niels Jessen Steen Bønløkke Pedersen Yvonne Böttcher Matthias Blüher Antje Körner Laurie J. Goodyear Moosa Mohammadi C. Ronald Kahn Yu-Hua Tseng |
| author_sort |
Farnaz Shamsi |
| title |
FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis |
| title_short |
FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis |
| title_full |
FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis |
| title_fullStr |
FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis |
| title_full_unstemmed |
FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis |
| title_sort |
fgf6 and fgf9 regulate ucp1 expression independent of brown adipogenesis |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/de377e337a5a402280aaea762fc97cbe |
| work_keys_str_mv |
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| _version_ |
1718390141059334144 |