Advances in Biological Functions and Clinical Studies of FGF21

Wei Lin,1 Tianlei Zhang,1 Yiyang Zhou,2 Jinyu Zheng,2 Zhenlang Lin1 1Department of Pediatrics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, People’s Republic of China; 2Wenzhou Medical University, Wenzhou, 325000, Zhejiang, P...

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Autores principales:	Lin W, Zhang T, Zhou Y, Zheng J, Lin Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	fibroblast growth factor21 molecular mechanisms metabolic modulation protective effect clinical application Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/de394f5cd9df42f0802760c36f338ac1
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spelling	oai:doaj.org-article:de394f5cd9df42f0802760c36f338ac12021-12-02T17:55:07ZAdvances in Biological Functions and Clinical Studies of FGF211178-7007https://doaj.org/article/de394f5cd9df42f0802760c36f338ac12021-07-01T00:00:00Zhttps://www.dovepress.com/advances-in-biological-functions-and-clinical-studies-of-fgf21-peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Wei Lin,1 Tianlei Zhang,1 Yiyang Zhou,2 Jinyu Zheng,2 Zhenlang Lin1 1Department of Pediatrics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, People’s Republic of China; 2Wenzhou Medical University, Wenzhou, 325000, Zhejiang, People’s Republic of ChinaCorrespondence: Zhenlang LinDepartment of Pediatrics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, People’s Republic of ChinaEmail lzlprof2020@163.comAbstract: Fibroblast growth factor 21 (FGF21) regulates many crucial biological processes in human and mammals, particularly metabolic modulation and protective effect after injury. Therefore, determining complex regulatory mechanisms and elucidating the signaling pathway may greatly promote the prevention, diagnosis, and treatment of related injury and metabolic diseases. This review focused on the metabolic modulation and protective effect of FGF21 and summarized the molecular mechanisms and clinical research developments.Keywords: fibroblast growth factor 21, molecular mechanisms, metabolic modulation, protective effect, clinical applicationLin WZhang TZhou YZheng JLin ZDove Medical Pressarticlefibroblast growth factor21molecular mechanismsmetabolic modulationprotective effectclinical applicationSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 3281-3290 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	fibroblast growth factor21 molecular mechanisms metabolic modulation protective effect clinical application Specialties of internal medicine RC581-951
spellingShingle	fibroblast growth factor21 molecular mechanisms metabolic modulation protective effect clinical application Specialties of internal medicine RC581-951 Lin W Zhang T Zhou Y Zheng J Lin Z Advances in Biological Functions and Clinical Studies of FGF21
description	Wei Lin,1 Tianlei Zhang,1 Yiyang Zhou,2 Jinyu Zheng,2 Zhenlang Lin1 1Department of Pediatrics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, People’s Republic of China; 2Wenzhou Medical University, Wenzhou, 325000, Zhejiang, People’s Republic of ChinaCorrespondence: Zhenlang LinDepartment of Pediatrics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, People’s Republic of ChinaEmail lzlprof2020@163.comAbstract: Fibroblast growth factor 21 (FGF21) regulates many crucial biological processes in human and mammals, particularly metabolic modulation and protective effect after injury. Therefore, determining complex regulatory mechanisms and elucidating the signaling pathway may greatly promote the prevention, diagnosis, and treatment of related injury and metabolic diseases. This review focused on the metabolic modulation and protective effect of FGF21 and summarized the molecular mechanisms and clinical research developments.Keywords: fibroblast growth factor 21, molecular mechanisms, metabolic modulation, protective effect, clinical application
format	article
author	Lin W Zhang T Zhou Y Zheng J Lin Z
author_facet	Lin W Zhang T Zhou Y Zheng J Lin Z
author_sort	Lin W
title	Advances in Biological Functions and Clinical Studies of FGF21
title_short	Advances in Biological Functions and Clinical Studies of FGF21
title_full	Advances in Biological Functions and Clinical Studies of FGF21
title_fullStr	Advances in Biological Functions and Clinical Studies of FGF21
title_full_unstemmed	Advances in Biological Functions and Clinical Studies of FGF21
title_sort	advances in biological functions and clinical studies of fgf21
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/de394f5cd9df42f0802760c36f338ac1
work_keys_str_mv	AT linw advancesinbiologicalfunctionsandclinicalstudiesoffgf21 AT zhangt advancesinbiologicalfunctionsandclinicalstudiesoffgf21 AT zhouy advancesinbiologicalfunctionsandclinicalstudiesoffgf21 AT zhengj advancesinbiologicalfunctionsandclinicalstudiesoffgf21 AT linz advancesinbiologicalfunctionsandclinicalstudiesoffgf21
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Advances in Biological Functions and Clinical Studies of FGF21

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