Vitamin D upregulates the macrophage complement receptor immunoglobulin in innate immunity to microbial pathogens

Annabelle Small et al. report a new role for vitamin D in innate immunity. They find that the vitamin D metabolite 1,25D increases phagocytosis and expression of complement receptor immunoglobulin (CRIg) by macrophages and that treatment of macrophages with a toll like receptor 2 agonist promotes co...

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Autores principales:	Annabelle G. Small, Sarah Harvey, Jaspreet Kaur, Trishni Putty, Alex Quach, Usma Munawara, Khalida Perveen, Andrew McPhee, Charles S. Hii, Antonio Ferrante
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/de3f7b20f6614ca2a57489563de761ba
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spelling	oai:doaj.org-article:de3f7b20f6614ca2a57489563de761ba2021-12-02T11:44:59ZVitamin D upregulates the macrophage complement receptor immunoglobulin in innate immunity to microbial pathogens10.1038/s42003-021-01943-32399-3642https://doaj.org/article/de3f7b20f6614ca2a57489563de761ba2021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01943-3https://doaj.org/toc/2399-3642Annabelle Small et al. report a new role for vitamin D in innate immunity. They find that the vitamin D metabolite 1,25D increases phagocytosis and expression of complement receptor immunoglobulin (CRIg) by macrophages and that treatment of macrophages with a toll like receptor 2 agonist promotes conversion of 25-hydroxyvitamin D3 to 1,25D.Annabelle G. SmallSarah HarveyJaspreet KaurTrishni PuttyAlex QuachUsma MunawaraKhalida PerveenAndrew McPheeCharles S. HiiAntonio FerranteNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Annabelle G. Small Sarah Harvey Jaspreet Kaur Trishni Putty Alex Quach Usma Munawara Khalida Perveen Andrew McPhee Charles S. Hii Antonio Ferrante Vitamin D upregulates the macrophage complement receptor immunoglobulin in innate immunity to microbial pathogens
description	Annabelle Small et al. report a new role for vitamin D in innate immunity. They find that the vitamin D metabolite 1,25D increases phagocytosis and expression of complement receptor immunoglobulin (CRIg) by macrophages and that treatment of macrophages with a toll like receptor 2 agonist promotes conversion of 25-hydroxyvitamin D3 to 1,25D.
format	article
author	Annabelle G. Small Sarah Harvey Jaspreet Kaur Trishni Putty Alex Quach Usma Munawara Khalida Perveen Andrew McPhee Charles S. Hii Antonio Ferrante
author_facet	Annabelle G. Small Sarah Harvey Jaspreet Kaur Trishni Putty Alex Quach Usma Munawara Khalida Perveen Andrew McPhee Charles S. Hii Antonio Ferrante
author_sort	Annabelle G. Small
title	Vitamin D upregulates the macrophage complement receptor immunoglobulin in innate immunity to microbial pathogens
title_short	Vitamin D upregulates the macrophage complement receptor immunoglobulin in innate immunity to microbial pathogens
title_full	Vitamin D upregulates the macrophage complement receptor immunoglobulin in innate immunity to microbial pathogens
title_fullStr	Vitamin D upregulates the macrophage complement receptor immunoglobulin in innate immunity to microbial pathogens
title_full_unstemmed	Vitamin D upregulates the macrophage complement receptor immunoglobulin in innate immunity to microbial pathogens
title_sort	vitamin d upregulates the macrophage complement receptor immunoglobulin in innate immunity to microbial pathogens
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/de3f7b20f6614ca2a57489563de761ba
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Vitamin D upregulates the macrophage complement receptor immunoglobulin in innate immunity to microbial pathogens

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