Small-animal PET imaging of amyloid-beta plaques with [11C]PiB and its multi-modal validation in an APP/PS1 mouse model of Alzheimer's disease.

Small-animal PET imaging of amyloid-beta plaques with [11C]PiB and its multi-modal validation in an APP/PS1 mouse model of Alzheimer's disease.

In vivo imaging and quantification of amyloid-β plaque (Aβ) burden in small-animal models of Alzheimer's disease (AD) is a valuable tool for translational research such as developing specific imaging markers and monitoring new therapy approaches. Methodological constraints such as image resolut...

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Bibliographic Details
Main Authors: André Manook, Behrooz H Yousefi, Antje Willuweit, Stefan Platzer, Sybille Reder, Andreas Voss, Marc Huisman, Markus Settles, Frauke Neff, Joachim Velden, Michael Schoor, Heinz von der Kammer, Hans-Jürgen Wester, Markus Schwaiger, Gjermund Henriksen, Alexander Drzezga
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2012
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/de3fe45cefe545f0bc8727bd2b9c0fdd
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https://doaj.org/article/de3fe45cefe545f0bc8727bd2b9c0fdd

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