Distinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance

Astrocytic GPCRs activate Ca2+ and cAMP signaling pathways, however, the in vivo dynamics of the two second messengers have not been fully been characterized. The authors demonstrate distinct noradrenaline-induced astrocytic Ca2+ and cAMP dynamics during startle and fear conditioning.

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Autores principales:	Yuki Oe, Xiaowen Wang, Tommaso Patriarchi, Ayumu Konno, Katsuya Ozawa, Kazuko Yahagi, Hirokazu Hirai, Takashi Tsuboi, Tetsuya Kitaguchi, Lin Tian, Thomas J. McHugh, Hajime Hirase
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/de4152a6e93445c59df4faa68661c234
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spelling	oai:doaj.org-article:de4152a6e93445c59df4faa68661c2342021-12-02T15:39:08ZDistinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance10.1038/s41467-020-14378-x2041-1723https://doaj.org/article/de4152a6e93445c59df4faa68661c2342020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14378-xhttps://doaj.org/toc/2041-1723Astrocytic GPCRs activate Ca2+ and cAMP signaling pathways, however, the in vivo dynamics of the two second messengers have not been fully been characterized. The authors demonstrate distinct noradrenaline-induced astrocytic Ca2+ and cAMP dynamics during startle and fear conditioning.Yuki OeXiaowen WangTommaso PatriarchiAyumu KonnoKatsuya OzawaKazuko YahagiHirokazu HiraiTakashi TsuboiTetsuya KitaguchiLin TianThomas J. McHughHajime HiraseNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuki Oe Xiaowen Wang Tommaso Patriarchi Ayumu Konno Katsuya Ozawa Kazuko Yahagi Hirokazu Hirai Takashi Tsuboi Tetsuya Kitaguchi Lin Tian Thomas J. McHugh Hajime Hirase Distinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance
description	Astrocytic GPCRs activate Ca2+ and cAMP signaling pathways, however, the in vivo dynamics of the two second messengers have not been fully been characterized. The authors demonstrate distinct noradrenaline-induced astrocytic Ca2+ and cAMP dynamics during startle and fear conditioning.
format	article
author	Yuki Oe Xiaowen Wang Tommaso Patriarchi Ayumu Konno Katsuya Ozawa Kazuko Yahagi Hirokazu Hirai Takashi Tsuboi Tetsuya Kitaguchi Lin Tian Thomas J. McHugh Hajime Hirase
author_facet	Yuki Oe Xiaowen Wang Tommaso Patriarchi Ayumu Konno Katsuya Ozawa Kazuko Yahagi Hirokazu Hirai Takashi Tsuboi Tetsuya Kitaguchi Lin Tian Thomas J. McHugh Hajime Hirase
author_sort	Yuki Oe
title	Distinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance
title_short	Distinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance
title_full	Distinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance
title_fullStr	Distinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance
title_full_unstemmed	Distinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance
title_sort	distinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/de4152a6e93445c59df4faa68661c234
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Distinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance

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