Molecular genetics of surfactin and its effects on different sub-populations of Bacillus subtilis

Surfactin is a biosurfactant produced by Bacillus subtilis. The srfA operon, Sfp gene, and two quorum sensing systems are required for its production. The master regulator spo0A also plays an indispensable role in proper surfactin synthesis. Upon production, surfactin itself acts as a signaling mole...

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Autores principales:	Faisal Bin Rahman, Bishajit Sarkar, Ripa Moni, Mohammad Shahedur Rahman
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Surfactin srfA operon Cell differentiation Bacillus subtilis Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/de4671d8ec2f408c8898391e0c8cf909
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spelling	oai:doaj.org-article:de4671d8ec2f408c8898391e0c8cf9092021-11-06T04:29:29ZMolecular genetics of surfactin and its effects on different sub-populations of Bacillus subtilis2215-017X10.1016/j.btre.2021.e00686https://doaj.org/article/de4671d8ec2f408c8898391e0c8cf9092021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2215017X21001028https://doaj.org/toc/2215-017XSurfactin is a biosurfactant produced by Bacillus subtilis. The srfA operon, Sfp gene, and two quorum sensing systems are required for its production. The master regulator spo0A also plays an indispensable role in proper surfactin synthesis. Upon production, surfactin itself acts as a signaling molecule and triggers the activation of Spo0A gene which in turn regulates cell differentiation. Interestingly, surfactin producing cells are immune to the action of surfactin but trigger other cells to differentiate into non-motile cells, matrix producing cells, cannibals, and spores. In case of competent cell differentiation, comS, which resides within the srfA operon, is co-expressed along with surfactin and plays a vital role in competent cell differentiation in response to quorum sensing signal. Surfactin inhibits the motility of certain cell subpopulations, although it helps the non-motile cells to swarm. Thus, surfactin plays significant roles in the differentiation of different subpopulations of specialized cell types of B. subtilis.Faisal Bin RahmanBishajit SarkarRipa MoniMohammad Shahedur RahmanElsevierarticleSurfactinsrfA operonCell differentiationBacillus subtilisBiotechnologyTP248.13-248.65ENBiotechnology Reports, Vol 32, Iss , Pp e00686- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Surfactin srfA operon Cell differentiation Bacillus subtilis Biotechnology TP248.13-248.65
spellingShingle	Surfactin srfA operon Cell differentiation Bacillus subtilis Biotechnology TP248.13-248.65 Faisal Bin Rahman Bishajit Sarkar Ripa Moni Mohammad Shahedur Rahman Molecular genetics of surfactin and its effects on different sub-populations of Bacillus subtilis
description	Surfactin is a biosurfactant produced by Bacillus subtilis. The srfA operon, Sfp gene, and two quorum sensing systems are required for its production. The master regulator spo0A also plays an indispensable role in proper surfactin synthesis. Upon production, surfactin itself acts as a signaling molecule and triggers the activation of Spo0A gene which in turn regulates cell differentiation. Interestingly, surfactin producing cells are immune to the action of surfactin but trigger other cells to differentiate into non-motile cells, matrix producing cells, cannibals, and spores. In case of competent cell differentiation, comS, which resides within the srfA operon, is co-expressed along with surfactin and plays a vital role in competent cell differentiation in response to quorum sensing signal. Surfactin inhibits the motility of certain cell subpopulations, although it helps the non-motile cells to swarm. Thus, surfactin plays significant roles in the differentiation of different subpopulations of specialized cell types of B. subtilis.
format	article
author	Faisal Bin Rahman Bishajit Sarkar Ripa Moni Mohammad Shahedur Rahman
author_facet	Faisal Bin Rahman Bishajit Sarkar Ripa Moni Mohammad Shahedur Rahman
author_sort	Faisal Bin Rahman
title	Molecular genetics of surfactin and its effects on different sub-populations of Bacillus subtilis
title_short	Molecular genetics of surfactin and its effects on different sub-populations of Bacillus subtilis
title_full	Molecular genetics of surfactin and its effects on different sub-populations of Bacillus subtilis
title_fullStr	Molecular genetics of surfactin and its effects on different sub-populations of Bacillus subtilis
title_full_unstemmed	Molecular genetics of surfactin and its effects on different sub-populations of Bacillus subtilis
title_sort	molecular genetics of surfactin and its effects on different sub-populations of bacillus subtilis
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/de4671d8ec2f408c8898391e0c8cf909
work_keys_str_mv	AT faisalbinrahman moleculargeneticsofsurfactinanditseffectsondifferentsubpopulationsofbacillussubtilis AT bishajitsarkar moleculargeneticsofsurfactinanditseffectsondifferentsubpopulationsofbacillussubtilis AT ripamoni moleculargeneticsofsurfactinanditseffectsondifferentsubpopulationsofbacillussubtilis AT mohammadshahedurrahman moleculargeneticsofsurfactinanditseffectsondifferentsubpopulationsofbacillussubtilis
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Molecular genetics of surfactin and its effects on different sub-populations of Bacillus subtilis

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