Emergence of the Novel Aminoglycoside Acetyltransferase Variant <italic toggle="yes">aac(6′)-Ib-D179Y</italic> and Acquisition of Colistin Heteroresistance in Carbapenem-Resistant <italic toggle="yes">Klebsiella pneumoniae</italic> Due to a Disrupting Mutation in the DNA Repair Enzyme MutS

Emergence of the Novel Aminoglycoside Acetyltransferase Variant <italic toggle="yes">aac(6′)-Ib-D179Y</italic> and Acquisition of Colistin Heteroresistance in Carbapenem-Resistant <italic toggle="yes">Klebsiella pneumoniae</italic> Due to a Disrupting Mutation in the DNA Repair Enzyme MutS

ABSTRACT Amikacin and colistin are effective against carbapenem-resistant Klebsiella pneumoniae. In 2017, we successively isolated three carbapenem-resistant K. pneumoniae isolates (ST967) from a patient with chronic renal failure in Japan. The first (SMKP01, sputum, day 0) and second (SMKP02, blood...

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Autores principales: Toyotaka Sato, Takayuki Wada, Suguru Nishijima, Yukari Fukushima, Chie Nakajima, Yasuhiko Suzuki, Satoshi Takahashi, Shin-ichi Yokota
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2020
Materias:
antimicrobial resistance
mutS
qnrB91
aac(6′)-Ib-D179Y
amikacin resistance
colistin resistance
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/de48a7d2501a48bcb18ba27fc93d5f06
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