Assessment of the role of ageing and non-ageing factors in death from non-communicable diseases based on a cumulative frequency model

Abstract To quantify the effects of ageing and non-ageing factors, a characterization of the effects of ageing, genetic, and exogenous variables on 12 major non-communicable diseases was evaluated using a model assessing cumulative frequency of death and survival by age group from dead and surviving...

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Autor principal:	Liu Hui
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/de4a622287bf4a7297c44eb1afd40bac
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spelling	oai:doaj.org-article:de4a622287bf4a7297c44eb1afd40bac2021-12-02T15:05:06ZAssessment of the role of ageing and non-ageing factors in death from non-communicable diseases based on a cumulative frequency model10.1038/s41598-017-08539-02045-2322https://doaj.org/article/de4a622287bf4a7297c44eb1afd40bac2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08539-0https://doaj.org/toc/2045-2322Abstract To quantify the effects of ageing and non-ageing factors, a characterization of the effects of ageing, genetic, and exogenous variables on 12 major non-communicable diseases was evaluated using a model assessing cumulative frequency of death and survival by age group from dead and surviving populations based on mortality statistics. Indices (0–1) of the roles of ageing (ARD), genetics (GRD) and exogenous (ERD) variables in deaths due to disease were established, and the sum of ARD, GRD and ERD was 1 (value of each indices was <1). Results showed that ageing plays an important role in death from chronic disease; exogenous factors may contribute more to the pattern of chronic disease than genetic factors (ARD, GRC and ERD were 0.818, 0.058 and 0.124 respectively for all non-communicable diseases). In descending order, ERD for non-communicable diseases were breast cancer, leukaemia, cancer of the cervix uteri and uterus, liver cancer, nephritis and nephropathy, stomach cancer, lung cancer, diabetes, cerebrovascular disease, coronary heart disease, COPD, and Alzheimer’s disease, while a smaller ERD indicated a tendency of natural death. An understanding of the aforementioned complex relationships of specific non-communicable diseases will be beneficial in designing primary prevention measures for non-communicable diseases in China.Liu HuiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Liu Hui Assessment of the role of ageing and non-ageing factors in death from non-communicable diseases based on a cumulative frequency model
description	Abstract To quantify the effects of ageing and non-ageing factors, a characterization of the effects of ageing, genetic, and exogenous variables on 12 major non-communicable diseases was evaluated using a model assessing cumulative frequency of death and survival by age group from dead and surviving populations based on mortality statistics. Indices (0–1) of the roles of ageing (ARD), genetics (GRD) and exogenous (ERD) variables in deaths due to disease were established, and the sum of ARD, GRD and ERD was 1 (value of each indices was <1). Results showed that ageing plays an important role in death from chronic disease; exogenous factors may contribute more to the pattern of chronic disease than genetic factors (ARD, GRC and ERD were 0.818, 0.058 and 0.124 respectively for all non-communicable diseases). In descending order, ERD for non-communicable diseases were breast cancer, leukaemia, cancer of the cervix uteri and uterus, liver cancer, nephritis and nephropathy, stomach cancer, lung cancer, diabetes, cerebrovascular disease, coronary heart disease, COPD, and Alzheimer’s disease, while a smaller ERD indicated a tendency of natural death. An understanding of the aforementioned complex relationships of specific non-communicable diseases will be beneficial in designing primary prevention measures for non-communicable diseases in China.
format	article
author	Liu Hui
author_facet	Liu Hui
author_sort	Liu Hui
title	Assessment of the role of ageing and non-ageing factors in death from non-communicable diseases based on a cumulative frequency model
title_short	Assessment of the role of ageing and non-ageing factors in death from non-communicable diseases based on a cumulative frequency model
title_full	Assessment of the role of ageing and non-ageing factors in death from non-communicable diseases based on a cumulative frequency model
title_fullStr	Assessment of the role of ageing and non-ageing factors in death from non-communicable diseases based on a cumulative frequency model
title_full_unstemmed	Assessment of the role of ageing and non-ageing factors in death from non-communicable diseases based on a cumulative frequency model
title_sort	assessment of the role of ageing and non-ageing factors in death from non-communicable diseases based on a cumulative frequency model
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/de4a622287bf4a7297c44eb1afd40bac
work_keys_str_mv	AT liuhui assessmentoftheroleofageingandnonageingfactorsindeathfromnoncommunicablediseasesbasedonacumulativefrequencymodel
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Assessment of the role of ageing and non-ageing factors in death from non-communicable diseases based on a cumulative frequency model

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