Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive DNA demethylation in mammals
Active and passive demethylation pathways have been implicated in the genome-wide erasure of 5mC accompanying mammalian preimplantation development. Here the authors reveal a recently evolved, mammalian-specific pathway in which global hypomethylation is achieved by the coupling of active and passiv...
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Nature Portfolio
2020
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oai:doaj.org-article:de4c9930854d459f81d5177982c482222021-12-02T14:16:40ZRecent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive DNA demethylation in mammals10.1038/s41467-020-19603-12041-1723https://doaj.org/article/de4c9930854d459f81d5177982c482222020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19603-1https://doaj.org/toc/2041-1723Active and passive demethylation pathways have been implicated in the genome-wide erasure of 5mC accompanying mammalian preimplantation development. Here the authors reveal a recently evolved, mammalian-specific pathway in which global hypomethylation is achieved by the coupling of active and passive demethylation.Christopher B. MulhollandAtsuya NishiyamaJoel RyanRyohei NakamuraMerve YiğitIvo M. GlückCarina TrummerWeihua QinMichael D. BartoschekFranziska R. TraubeEdris ParsaEnes UgurMiha ModicAishwarya AcharyaPaul StolzChristoph ZiegenhainMichael WiererWolfgang EnardThomas CarellDon C. LambHiroyuki TakedaMakoto NakanishiSebastian BultmannHeinrich LeonhardtNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-24 (2020) |
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Science Q Christopher B. Mulholland Atsuya Nishiyama Joel Ryan Ryohei Nakamura Merve Yiğit Ivo M. Glück Carina Trummer Weihua Qin Michael D. Bartoschek Franziska R. Traube Edris Parsa Enes Ugur Miha Modic Aishwarya Acharya Paul Stolz Christoph Ziegenhain Michael Wierer Wolfgang Enard Thomas Carell Don C. Lamb Hiroyuki Takeda Makoto Nakanishi Sebastian Bultmann Heinrich Leonhardt Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive DNA demethylation in mammals |
| description |
Active and passive demethylation pathways have been implicated in the genome-wide erasure of 5mC accompanying mammalian preimplantation development. Here the authors reveal a recently evolved, mammalian-specific pathway in which global hypomethylation is achieved by the coupling of active and passive demethylation. |
| format |
article |
| author |
Christopher B. Mulholland Atsuya Nishiyama Joel Ryan Ryohei Nakamura Merve Yiğit Ivo M. Glück Carina Trummer Weihua Qin Michael D. Bartoschek Franziska R. Traube Edris Parsa Enes Ugur Miha Modic Aishwarya Acharya Paul Stolz Christoph Ziegenhain Michael Wierer Wolfgang Enard Thomas Carell Don C. Lamb Hiroyuki Takeda Makoto Nakanishi Sebastian Bultmann Heinrich Leonhardt |
| author_facet |
Christopher B. Mulholland Atsuya Nishiyama Joel Ryan Ryohei Nakamura Merve Yiğit Ivo M. Glück Carina Trummer Weihua Qin Michael D. Bartoschek Franziska R. Traube Edris Parsa Enes Ugur Miha Modic Aishwarya Acharya Paul Stolz Christoph Ziegenhain Michael Wierer Wolfgang Enard Thomas Carell Don C. Lamb Hiroyuki Takeda Makoto Nakanishi Sebastian Bultmann Heinrich Leonhardt |
| author_sort |
Christopher B. Mulholland |
| title |
Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive DNA demethylation in mammals |
| title_short |
Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive DNA demethylation in mammals |
| title_full |
Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive DNA demethylation in mammals |
| title_fullStr |
Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive DNA demethylation in mammals |
| title_full_unstemmed |
Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive DNA demethylation in mammals |
| title_sort |
recent evolution of a tet-controlled and dppa3/stella-driven pathway of passive dna demethylation in mammals |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/de4c9930854d459f81d5177982c48222 |
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