Protein–Nanoparticle Interaction: Corona Formation and Conformational Changes in Proteins on Nanoparticles

Protein–Nanoparticle Interaction: Corona Formation and Conformational Changes in Proteins on Nanoparticles

Sung Jean Park College of Pharmacy and Gachon Institute of Pharmaceutical Sciences, Gachon University, Incheon 21936, KoreaCorrespondence: Sung Jean ParkCollege of Pharmacy and Gachon Institute of Pharmaceutical Sciences, Gachon University, 191 Hambakmoero, Yeonsu-gu, Incheon 21936, KoreaEmail psjnm...

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Autor principal: Park SJ
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2020
Materias:
nanoparticle
protein corona
structure
surface characteristic
conformational change
Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/de508a96d70343e2a8ca504c1b799345
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spelling oai:doaj.org-article:de508a96d70343e2a8ca504c1b7993452021-12-02T11:07:24ZProtein–Nanoparticle Interaction: Corona Formation and Conformational Changes in Proteins on Nanoparticles1178-2013https://doaj.org/article/de508a96d70343e2a8ca504c1b7993452020-08-01T00:00:00Zhttps://www.dovepress.com/proteinndashnanoparticle-interaction-corona-formation-and-conformation-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Sung Jean Park College of Pharmacy and Gachon Institute of Pharmaceutical Sciences, Gachon University, Incheon 21936, KoreaCorrespondence: Sung Jean ParkCollege of Pharmacy and Gachon Institute of Pharmaceutical Sciences, Gachon University, 191 Hambakmoero, Yeonsu-gu, Incheon 21936, KoreaEmail psjnmr@gachon.ac.krAbstract: Nanoparticles (NPs) are highly potent tools for the diagnosis of diseases and specific delivery of therapeutic agents. Their development and application are scientifically and industrially important. The engineering of NPs and the modulation of their in vivo behavior have been extensively studied, and significant achievements have been made in the past decades. However, in vivo applications of NPs are often limited by several difficulties, including inflammatory responses and cellular toxicity, unexpected distribution and clearance from the body, and insufficient delivery to a specific target. These unfavorable phenomena may largely be related to the in vivo protein–NP interaction, termed “protein corona.” The layer of adsorbed proteins on the surface of NPs affects the biological behavior of NPs and changes their functionality, occasionally resulting in loss-of-function or gain-of-function. The formation of a protein corona is an intricate process involving complex kinetics and dynamics between the two interacting entities. Structural changes in corona proteins have been reported in many cases after their adsorption on the surfaces of NPs that strongly influence the functions of NPs. Thus, understanding of the conformational changes and unfolding process of proteins is very important to accelerate the biomedical applications of NPs. Here, we describe several protein corona characteristics and specifically focus on the conformational fluctuations in corona proteins induced by NPs.Keywords: nanoparticle, protein corona, structure, surface characteristic, conformational changePark SJDove Medical Pressarticlenanoparticleprotein coronastructuresurface characteristicconformational changeMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 5783-5802 (2020)
institution DOAJ
collection DOAJ
language EN
topic nanoparticle
protein corona
structure
surface characteristic
conformational change
Medicine (General)
R5-920
spellingShingle nanoparticle
protein corona
structure
surface characteristic
conformational change
Medicine (General)
R5-920
Park SJ
Protein–Nanoparticle Interaction: Corona Formation and Conformational Changes in Proteins on Nanoparticles
description Sung Jean Park College of Pharmacy and Gachon Institute of Pharmaceutical Sciences, Gachon University, Incheon 21936, KoreaCorrespondence: Sung Jean ParkCollege of Pharmacy and Gachon Institute of Pharmaceutical Sciences, Gachon University, 191 Hambakmoero, Yeonsu-gu, Incheon 21936, KoreaEmail psjnmr@gachon.ac.krAbstract: Nanoparticles (NPs) are highly potent tools for the diagnosis of diseases and specific delivery of therapeutic agents. Their development and application are scientifically and industrially important. The engineering of NPs and the modulation of their in vivo behavior have been extensively studied, and significant achievements have been made in the past decades. However, in vivo applications of NPs are often limited by several difficulties, including inflammatory responses and cellular toxicity, unexpected distribution and clearance from the body, and insufficient delivery to a specific target. These unfavorable phenomena may largely be related to the in vivo protein–NP interaction, termed “protein corona.” The layer of adsorbed proteins on the surface of NPs affects the biological behavior of NPs and changes their functionality, occasionally resulting in loss-of-function or gain-of-function. The formation of a protein corona is an intricate process involving complex kinetics and dynamics between the two interacting entities. Structural changes in corona proteins have been reported in many cases after their adsorption on the surfaces of NPs that strongly influence the functions of NPs. Thus, understanding of the conformational changes and unfolding process of proteins is very important to accelerate the biomedical applications of NPs. Here, we describe several protein corona characteristics and specifically focus on the conformational fluctuations in corona proteins induced by NPs.Keywords: nanoparticle, protein corona, structure, surface characteristic, conformational change
format article
author Park SJ
author_facet Park SJ
author_sort Park SJ
title Protein–Nanoparticle Interaction: Corona Formation and Conformational Changes in Proteins on Nanoparticles
title_short Protein–Nanoparticle Interaction: Corona Formation and Conformational Changes in Proteins on Nanoparticles
title_full Protein–Nanoparticle Interaction: Corona Formation and Conformational Changes in Proteins on Nanoparticles
title_fullStr Protein–Nanoparticle Interaction: Corona Formation and Conformational Changes in Proteins on Nanoparticles
title_full_unstemmed Protein–Nanoparticle Interaction: Corona Formation and Conformational Changes in Proteins on Nanoparticles
title_sort protein–nanoparticle interaction: corona formation and conformational changes in proteins on nanoparticles
publisher Dove Medical Press
publishDate 2020
url https://doaj.org/article/de508a96d70343e2a8ca504c1b799345
work_keys_str_mv AT parksj proteinndashnanoparticleinteractioncoronaformationandconformationalchangesinproteinsonnanoparticles
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