Intraperitoneal insulin infusion: on the way to the artificial pancreas

Creating an "artificial pancreas" (a "closed loop" insulin pump, with self-adjusting insulin abilities, based on real time continuous glucose monitoring data) – is one of the most actual medical challenges of modern engineering and cybernetics.Artificial pancreas (AP) prototypes...

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Autores principales:	Vladimir Aleksandrovich Karpel'ev, Elena Anatol'evna Fedorova, Yury Ivanovich Philippov, Aleksandr Yur'evich Mayorov, Marina Vladimirovna Shestakova
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2015
Materias:	insulin pump insulin pharmacokinetics intraperitoneal infusion diabetes mellitus artificial pancreas Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/de55be4fd4da4e3eb7b2354f0b78b6a6
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spelling	oai:doaj.org-article:de55be4fd4da4e3eb7b2354f0b78b6a62021-11-14T09:00:19ZIntraperitoneal insulin infusion: on the way to the artificial pancreas2072-03512072-037810.14341/DM2015332-45https://doaj.org/article/de55be4fd4da4e3eb7b2354f0b78b6a62015-10-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/7228https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Creating an "artificial pancreas" (a "closed loop" insulin pump, with self-adjusting insulin abilities, based on real time continuous glucose monitoring data) – is one of the most actual medical challenges of modern engineering and cybernetics.Artificial pancreas (AP) prototypes based on wearable insulin pump with subcutaneous insulin delivery are still problematic, mainly because of slow insulin pharmacokinetics. Intravenous insulin infusion via AP allows effectively maintain euglycaemia for inpatients, due to insulin pharmacokinetics and pharmacodynamics advantages. Unfortunately, it can’t be used for outpatients. Intraperitoneal insulin infusion is still relatively infrequently used in the world, but it is a promising alternative, compared to both previous methods due to a physiological action profile, fast insulin pharmacokinetics, relatively better safety and availability for outpatient usage.The purpose of this review is to describe the intraperitoneal insulin infusion features for diabetes patients at a point of AP creation perspectives.Vladimir Aleksandrovich Karpel'evElena Anatol'evna FedorovaYury Ivanovich PhilippovAleksandr Yur'evich MayorovMarina Vladimirovna ShestakovaEndocrinology Research Centrearticleinsulin pumpinsulinpharmacokineticsintraperitoneal infusiondiabetes mellitusartificial pancreasNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 18, Iss 3, Pp 32-45 (2015)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	insulin pump insulin pharmacokinetics intraperitoneal infusion diabetes mellitus artificial pancreas Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	insulin pump insulin pharmacokinetics intraperitoneal infusion diabetes mellitus artificial pancreas Nutritional diseases. Deficiency diseases RC620-627 Vladimir Aleksandrovich Karpel'ev Elena Anatol'evna Fedorova Yury Ivanovich Philippov Aleksandr Yur'evich Mayorov Marina Vladimirovna Shestakova Intraperitoneal insulin infusion: on the way to the artificial pancreas
description	Creating an "artificial pancreas" (a "closed loop" insulin pump, with self-adjusting insulin abilities, based on real time continuous glucose monitoring data) – is one of the most actual medical challenges of modern engineering and cybernetics.Artificial pancreas (AP) prototypes based on wearable insulin pump with subcutaneous insulin delivery are still problematic, mainly because of slow insulin pharmacokinetics. Intravenous insulin infusion via AP allows effectively maintain euglycaemia for inpatients, due to insulin pharmacokinetics and pharmacodynamics advantages. Unfortunately, it can’t be used for outpatients. Intraperitoneal insulin infusion is still relatively infrequently used in the world, but it is a promising alternative, compared to both previous methods due to a physiological action profile, fast insulin pharmacokinetics, relatively better safety and availability for outpatient usage.The purpose of this review is to describe the intraperitoneal insulin infusion features for diabetes patients at a point of AP creation perspectives.
format	article
author	Vladimir Aleksandrovich Karpel'ev Elena Anatol'evna Fedorova Yury Ivanovich Philippov Aleksandr Yur'evich Mayorov Marina Vladimirovna Shestakova
author_facet	Vladimir Aleksandrovich Karpel'ev Elena Anatol'evna Fedorova Yury Ivanovich Philippov Aleksandr Yur'evich Mayorov Marina Vladimirovna Shestakova
author_sort	Vladimir Aleksandrovich Karpel'ev
title	Intraperitoneal insulin infusion: on the way to the artificial pancreas
title_short	Intraperitoneal insulin infusion: on the way to the artificial pancreas
title_full	Intraperitoneal insulin infusion: on the way to the artificial pancreas
title_fullStr	Intraperitoneal insulin infusion: on the way to the artificial pancreas
title_full_unstemmed	Intraperitoneal insulin infusion: on the way to the artificial pancreas
title_sort	intraperitoneal insulin infusion: on the way to the artificial pancreas
publisher	Endocrinology Research Centre
publishDate	2015
url	https://doaj.org/article/de55be4fd4da4e3eb7b2354f0b78b6a6
work_keys_str_mv	AT vladimiraleksandrovichkarpelev intraperitonealinsulininfusiononthewaytotheartificialpancreas AT elenaanatolevnafedorova intraperitonealinsulininfusiononthewaytotheartificialpancreas AT yuryivanovichphilippov intraperitonealinsulininfusiononthewaytotheartificialpancreas AT aleksandryurevichmayorov intraperitonealinsulininfusiononthewaytotheartificialpancreas AT marinavladimirovnashestakova intraperitonealinsulininfusiononthewaytotheartificialpancreas
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Intraperitoneal insulin infusion: on the way to the artificial pancreas

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