Is the Course of COVID-19 Different during Pregnancy? A Retrospective Comparative Study

The COVID-19 pandemic has challenged health systems around the world. Maternal-foetal medicine, which has been particularly affected, must consider scientific data on the physiological processes occurring in the pregnant woman’s body to develop relevant standards of care. Our study retrospectively c...

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Autores principales:	Marcin Januszewski, Laura Ziuzia-Januszewska, Alicja A. Jakimiuk, Waldemar Wierzba, Anna Gluszko, Joanna Zytynska-Daniluk, Artur J. Jakimiuk
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	SARS-CoV-2 COVID-19 clinical course pregnancy oxygen flow inflammatory markers Medicine R
Acceso en línea:	https://doaj.org/article/de582d8a9dec45d39936d94f5e0dfb28
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spelling	oai:doaj.org-article:de582d8a9dec45d39936d94f5e0dfb282021-11-25T17:50:18ZIs the Course of COVID-19 Different during Pregnancy? A Retrospective Comparative Study10.3390/ijerph1822120111660-46011661-7827https://doaj.org/article/de582d8a9dec45d39936d94f5e0dfb282021-11-01T00:00:00Zhttps://www.mdpi.com/1660-4601/18/22/12011https://doaj.org/toc/1661-7827https://doaj.org/toc/1660-4601The COVID-19 pandemic has challenged health systems around the world. Maternal-foetal medicine, which has been particularly affected, must consider scientific data on the physiological processes occurring in the pregnant woman’s body to develop relevant standards of care. Our study retrospectively compared the clinical and laboratory characteristics of 52 COVID-19 pregnant patients with 53 controls. Most of the pregnant patients required medical attention during the third trimester and therefore we propose that vaccination is needed prior to the 30th week of pregnancy. We found no differences between the 2 groups in the course of illness classification system, days of hospital stay, need for oxygen supplementation, need for mechanical ventilation, and ICU admission. Moreover, clinical manifestations and imaging findings were comparable. Pregnant patients needed a greater oxygen flow rate and required high flow oxygen therapy more frequently. Considering pregnancy-related physiological adaptations, we found that COVID-19 infection in pregnant patients is associated with higher levels of inflammatory markers, apart from serum ferritin, than in non-pregnant women, and concluded that biomarkers of cardiac and muscle injury, as well as kidney function, may not be good predictors of COVID-19 clinical course in pregnant patients at the time of admission, but more research needs to be conducted on this topic.Marcin JanuszewskiLaura Ziuzia-JanuszewskaAlicja A. JakimiukWaldemar WierzbaAnna GluszkoJoanna Zytynska-DanilukArtur J. JakimiukMDPI AGarticleSARS-CoV-2COVID-19clinical coursepregnancyoxygen flowinflammatory markersMedicineRENInternational Journal of Environmental Research and Public Health, Vol 18, Iss 12011, p 12011 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	SARS-CoV-2 COVID-19 clinical course pregnancy oxygen flow inflammatory markers Medicine R
spellingShingle	SARS-CoV-2 COVID-19 clinical course pregnancy oxygen flow inflammatory markers Medicine R Marcin Januszewski Laura Ziuzia-Januszewska Alicja A. Jakimiuk Waldemar Wierzba Anna Gluszko Joanna Zytynska-Daniluk Artur J. Jakimiuk Is the Course of COVID-19 Different during Pregnancy? A Retrospective Comparative Study
description	The COVID-19 pandemic has challenged health systems around the world. Maternal-foetal medicine, which has been particularly affected, must consider scientific data on the physiological processes occurring in the pregnant woman’s body to develop relevant standards of care. Our study retrospectively compared the clinical and laboratory characteristics of 52 COVID-19 pregnant patients with 53 controls. Most of the pregnant patients required medical attention during the third trimester and therefore we propose that vaccination is needed prior to the 30th week of pregnancy. We found no differences between the 2 groups in the course of illness classification system, days of hospital stay, need for oxygen supplementation, need for mechanical ventilation, and ICU admission. Moreover, clinical manifestations and imaging findings were comparable. Pregnant patients needed a greater oxygen flow rate and required high flow oxygen therapy more frequently. Considering pregnancy-related physiological adaptations, we found that COVID-19 infection in pregnant patients is associated with higher levels of inflammatory markers, apart from serum ferritin, than in non-pregnant women, and concluded that biomarkers of cardiac and muscle injury, as well as kidney function, may not be good predictors of COVID-19 clinical course in pregnant patients at the time of admission, but more research needs to be conducted on this topic.
format	article
author	Marcin Januszewski Laura Ziuzia-Januszewska Alicja A. Jakimiuk Waldemar Wierzba Anna Gluszko Joanna Zytynska-Daniluk Artur J. Jakimiuk
author_facet	Marcin Januszewski Laura Ziuzia-Januszewska Alicja A. Jakimiuk Waldemar Wierzba Anna Gluszko Joanna Zytynska-Daniluk Artur J. Jakimiuk
author_sort	Marcin Januszewski
title	Is the Course of COVID-19 Different during Pregnancy? A Retrospective Comparative Study
title_short	Is the Course of COVID-19 Different during Pregnancy? A Retrospective Comparative Study
title_full	Is the Course of COVID-19 Different during Pregnancy? A Retrospective Comparative Study
title_fullStr	Is the Course of COVID-19 Different during Pregnancy? A Retrospective Comparative Study
title_full_unstemmed	Is the Course of COVID-19 Different during Pregnancy? A Retrospective Comparative Study
title_sort	is the course of covid-19 different during pregnancy? a retrospective comparative study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/de582d8a9dec45d39936d94f5e0dfb28
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Is the Course of COVID-19 Different during Pregnancy? A Retrospective Comparative Study

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