Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a

Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a

Uhrf1 is a known regulator of heterochromatin and DNA methylation in embryonic stem cells (ESCs). Here, the authors demonstrate that Uhrf1 acts together with the Set1/COMPASS complex regulator of active transcription to promote H3K4 methylation at bivalent loci and Uhrf1 loss results in disruption o...

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Autores principales: Kun-Yong Kim, Yoshiaki Tanaka, Juan Su, Bilal Cakir, Yangfei Xiang, Benjamin Patterson, Junjun Ding, Yong-Wook Jung, Ji-Hyun Kim, Eriona Hysolli, Haelim Lee, Rana Dajani, Jonghwan Kim, Mei Zhong, Jeong-Heon Lee, David Skalnik, Jeong Mook Lim, Gareth J. Sullivan, Jianlong Wang, In-Hyun Park
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/de5d0fb025b047ba960f4909f2822905
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spelling oai:doaj.org-article:de5d0fb025b047ba960f4909f28229052021-12-02T17:32:19ZUhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a10.1038/s41467-018-04818-02041-1723https://doaj.org/article/de5d0fb025b047ba960f4909f28229052018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04818-0https://doaj.org/toc/2041-1723Uhrf1 is a known regulator of heterochromatin and DNA methylation in embryonic stem cells (ESCs). Here, the authors demonstrate that Uhrf1 acts together with the Set1/COMPASS complex regulator of active transcription to promote H3K4 methylation at bivalent loci and Uhrf1 loss results in disruption of differentiation.Kun-Yong KimYoshiaki TanakaJuan SuBilal CakirYangfei XiangBenjamin PattersonJunjun DingYong-Wook JungJi-Hyun KimEriona HysolliHaelim LeeRana DajaniJonghwan KimMei ZhongJeong-Heon LeeDavid SkalnikJeong Mook LimGareth J. SullivanJianlong WangIn-Hyun ParkNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Kun-Yong Kim
Yoshiaki Tanaka
Juan Su
Bilal Cakir
Yangfei Xiang
Benjamin Patterson
Junjun Ding
Yong-Wook Jung
Ji-Hyun Kim
Eriona Hysolli
Haelim Lee
Rana Dajani
Jonghwan Kim
Mei Zhong
Jeong-Heon Lee
David Skalnik
Jeong Mook Lim
Gareth J. Sullivan
Jianlong Wang
In-Hyun Park
Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a
description Uhrf1 is a known regulator of heterochromatin and DNA methylation in embryonic stem cells (ESCs). Here, the authors demonstrate that Uhrf1 acts together with the Set1/COMPASS complex regulator of active transcription to promote H3K4 methylation at bivalent loci and Uhrf1 loss results in disruption of differentiation.
format article
author Kun-Yong Kim
Yoshiaki Tanaka
Juan Su
Bilal Cakir
Yangfei Xiang
Benjamin Patterson
Junjun Ding
Yong-Wook Jung
Ji-Hyun Kim
Eriona Hysolli
Haelim Lee
Rana Dajani
Jonghwan Kim
Mei Zhong
Jeong-Heon Lee
David Skalnik
Jeong Mook Lim
Gareth J. Sullivan
Jianlong Wang
In-Hyun Park
author_facet Kun-Yong Kim
Yoshiaki Tanaka
Juan Su
Bilal Cakir
Yangfei Xiang
Benjamin Patterson
Junjun Ding
Yong-Wook Jung
Ji-Hyun Kim
Eriona Hysolli
Haelim Lee
Rana Dajani
Jonghwan Kim
Mei Zhong
Jeong-Heon Lee
David Skalnik
Jeong Mook Lim
Gareth J. Sullivan
Jianlong Wang
In-Hyun Park
author_sort Kun-Yong Kim
title Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a
title_short Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a
title_full Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a
title_fullStr Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a
title_full_unstemmed Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a
title_sort uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through setd1a
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/de5d0fb025b047ba960f4909f2822905
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