Associations between subjective well-being and subcortical brain volumes

Abstract To study the underpinnings of individual differences in subjective well-being (SWB), we tested for associations of SWB with subcortical brain volumes in a dataset of 724 twins and siblings. For significant SWB-brain associations we probed for causal pathways using Mendelian Randomization (M...

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Autores principales:	D. Van ‘t Ent, A. den Braber, B. M. L. Baselmans, R. M. Brouwer, C. V. Dolan, H. E. Hulshoff Pol, E. J. C. de Geus, M. Bartels
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Subcortical Brain Volumes Subjective Well-being (SWB) Hippocampal Volume Twin Model Mendelian Randomization (MR) Medicine R Science Q
Acceso en línea:	https://doaj.org/article/de5f609ca9d34f3abd4ba488e27ba6a3
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spelling	oai:doaj.org-article:de5f609ca9d34f3abd4ba488e27ba6a32021-12-02T11:41:08ZAssociations between subjective well-being and subcortical brain volumes10.1038/s41598-017-07120-z2045-2322https://doaj.org/article/de5f609ca9d34f3abd4ba488e27ba6a32017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07120-zhttps://doaj.org/toc/2045-2322Abstract To study the underpinnings of individual differences in subjective well-being (SWB), we tested for associations of SWB with subcortical brain volumes in a dataset of 724 twins and siblings. For significant SWB-brain associations we probed for causal pathways using Mendelian Randomization (MR) and estimated genetic and environmental contributions from twin modeling. Another independent measure of genetic correlation was obtained from linkage disequilibrium (LD) score regression on published genome-wide association summary statistics. Our results indicated associations of SWB with hippocampal volumes but not with volumes of the basal ganglia, thalamus, amygdala, or nucleus accumbens. The SWB-hippocampus relations were nonlinear and characterized by lower SWB in subjects with relatively smaller hippocampal volumes compared to subjects with medium and higher hippocampal volumes. MR provided no evidence for an SWB to hippocampal volume or hippocampal volume to SWB pathway. This was in line with twin modeling and LD-score regression results which indicated non-significant genetic correlations. We conclude that low SWB is associated with smaller hippocampal volume, but that genes are not very important in this relationship. Instead other etiological factors, such as exposure to stress and stress hormones, may exert detrimental effects on SWB and the hippocampus to bring about the observed association.D. Van ‘t EntA. den BraberB. M. L. BaselmansR. M. BrouwerC. V. DolanH. E. Hulshoff PolE. J. C. de GeusM. BartelsNature PortfolioarticleSubcortical Brain VolumesSubjective Well-being (SWB)Hippocampal VolumeTwin ModelMendelian Randomization (MR)MedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Subcortical Brain Volumes Subjective Well-being (SWB) Hippocampal Volume Twin Model Mendelian Randomization (MR) Medicine R Science Q
spellingShingle	Subcortical Brain Volumes Subjective Well-being (SWB) Hippocampal Volume Twin Model Mendelian Randomization (MR) Medicine R Science Q D. Van ‘t Ent A. den Braber B. M. L. Baselmans R. M. Brouwer C. V. Dolan H. E. Hulshoff Pol E. J. C. de Geus M. Bartels Associations between subjective well-being and subcortical brain volumes
description	Abstract To study the underpinnings of individual differences in subjective well-being (SWB), we tested for associations of SWB with subcortical brain volumes in a dataset of 724 twins and siblings. For significant SWB-brain associations we probed for causal pathways using Mendelian Randomization (MR) and estimated genetic and environmental contributions from twin modeling. Another independent measure of genetic correlation was obtained from linkage disequilibrium (LD) score regression on published genome-wide association summary statistics. Our results indicated associations of SWB with hippocampal volumes but not with volumes of the basal ganglia, thalamus, amygdala, or nucleus accumbens. The SWB-hippocampus relations were nonlinear and characterized by lower SWB in subjects with relatively smaller hippocampal volumes compared to subjects with medium and higher hippocampal volumes. MR provided no evidence for an SWB to hippocampal volume or hippocampal volume to SWB pathway. This was in line with twin modeling and LD-score regression results which indicated non-significant genetic correlations. We conclude that low SWB is associated with smaller hippocampal volume, but that genes are not very important in this relationship. Instead other etiological factors, such as exposure to stress and stress hormones, may exert detrimental effects on SWB and the hippocampus to bring about the observed association.
format	article
author	D. Van ‘t Ent A. den Braber B. M. L. Baselmans R. M. Brouwer C. V. Dolan H. E. Hulshoff Pol E. J. C. de Geus M. Bartels
author_facet	D. Van ‘t Ent A. den Braber B. M. L. Baselmans R. M. Brouwer C. V. Dolan H. E. Hulshoff Pol E. J. C. de Geus M. Bartels
author_sort	D. Van ‘t Ent
title	Associations between subjective well-being and subcortical brain volumes
title_short	Associations between subjective well-being and subcortical brain volumes
title_full	Associations between subjective well-being and subcortical brain volumes
title_fullStr	Associations between subjective well-being and subcortical brain volumes
title_full_unstemmed	Associations between subjective well-being and subcortical brain volumes
title_sort	associations between subjective well-being and subcortical brain volumes
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/de5f609ca9d34f3abd4ba488e27ba6a3
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Associations between subjective well-being and subcortical brain volumes

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