Heterologous protection against malaria by a simple chemoattenuated PfSPZ vaccine regimen in a randomized trial
In this placebo-controlled trial, 10/13 malaria naïve subjects immunized with a simplified regimen of chemoattenuated P. falciparum sporozoites, PfSPZ-CVac, show sterile protection from heterologous malaria challenge. Immunization was well tolerated and induced high levels of anti-PfCSP antibodies.
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Nature Portfolio
2021
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oai:doaj.org-article:de6161831021472293648f15342062a52021-12-02T14:49:41ZHeterologous protection against malaria by a simple chemoattenuated PfSPZ vaccine regimen in a randomized trial10.1038/s41467-021-22740-w2041-1723https://doaj.org/article/de6161831021472293648f15342062a52021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22740-whttps://doaj.org/toc/2041-1723In this placebo-controlled trial, 10/13 malaria naïve subjects immunized with a simplified regimen of chemoattenuated P. falciparum sporozoites, PfSPZ-CVac, show sterile protection from heterologous malaria challenge. Immunization was well tolerated and induced high levels of anti-PfCSP antibodies.Zita SulyokRolf FendelBianca EderFreia-Raphaella LorenzNatasha KCMatthias KarnahlAlbert LalremruataThe T. NguyenJana HeldFolashade Almeine Cyntiche AdjadiTorsten KlockenbringJudith FlüggeTamirat Gebru WoldearegaiCarlos Lamsfus CalleJavier IbáñezMiriam RodiDiane Egger-AdamAndrea KreidenweissCarsten KöhlerMeral EsenMihály SulyokAnita ManojThomas L. RichieB. Kim Lee SimStephen L. HoffmanBenjamin MordmüllerPeter G. KremsnerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021) |
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Science Q Zita Sulyok Rolf Fendel Bianca Eder Freia-Raphaella Lorenz Natasha KC Matthias Karnahl Albert Lalremruata The T. Nguyen Jana Held Folashade Almeine Cyntiche Adjadi Torsten Klockenbring Judith Flügge Tamirat Gebru Woldearegai Carlos Lamsfus Calle Javier Ibáñez Miriam Rodi Diane Egger-Adam Andrea Kreidenweiss Carsten Köhler Meral Esen Mihály Sulyok Anita Manoj Thomas L. Richie B. Kim Lee Sim Stephen L. Hoffman Benjamin Mordmüller Peter G. Kremsner Heterologous protection against malaria by a simple chemoattenuated PfSPZ vaccine regimen in a randomized trial |
| description |
In this placebo-controlled trial, 10/13 malaria naïve subjects immunized with a simplified regimen of chemoattenuated P. falciparum sporozoites, PfSPZ-CVac, show sterile protection from heterologous malaria challenge. Immunization was well tolerated and induced high levels of anti-PfCSP antibodies. |
| format |
article |
| author |
Zita Sulyok Rolf Fendel Bianca Eder Freia-Raphaella Lorenz Natasha KC Matthias Karnahl Albert Lalremruata The T. Nguyen Jana Held Folashade Almeine Cyntiche Adjadi Torsten Klockenbring Judith Flügge Tamirat Gebru Woldearegai Carlos Lamsfus Calle Javier Ibáñez Miriam Rodi Diane Egger-Adam Andrea Kreidenweiss Carsten Köhler Meral Esen Mihály Sulyok Anita Manoj Thomas L. Richie B. Kim Lee Sim Stephen L. Hoffman Benjamin Mordmüller Peter G. Kremsner |
| author_facet |
Zita Sulyok Rolf Fendel Bianca Eder Freia-Raphaella Lorenz Natasha KC Matthias Karnahl Albert Lalremruata The T. Nguyen Jana Held Folashade Almeine Cyntiche Adjadi Torsten Klockenbring Judith Flügge Tamirat Gebru Woldearegai Carlos Lamsfus Calle Javier Ibáñez Miriam Rodi Diane Egger-Adam Andrea Kreidenweiss Carsten Köhler Meral Esen Mihály Sulyok Anita Manoj Thomas L. Richie B. Kim Lee Sim Stephen L. Hoffman Benjamin Mordmüller Peter G. Kremsner |
| author_sort |
Zita Sulyok |
| title |
Heterologous protection against malaria by a simple chemoattenuated PfSPZ vaccine regimen in a randomized trial |
| title_short |
Heterologous protection against malaria by a simple chemoattenuated PfSPZ vaccine regimen in a randomized trial |
| title_full |
Heterologous protection against malaria by a simple chemoattenuated PfSPZ vaccine regimen in a randomized trial |
| title_fullStr |
Heterologous protection against malaria by a simple chemoattenuated PfSPZ vaccine regimen in a randomized trial |
| title_full_unstemmed |
Heterologous protection against malaria by a simple chemoattenuated PfSPZ vaccine regimen in a randomized trial |
| title_sort |
heterologous protection against malaria by a simple chemoattenuated pfspz vaccine regimen in a randomized trial |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/de6161831021472293648f15342062a5 |
| work_keys_str_mv |
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