The FlgN chaperone activates the Na+-driven engine of the Salmonella flagellar protein export apparatus

Minamino et al. report that the bacterial FlgN chaperone acts as a switch to activate a backup mechanism for H+-coupled flagellar protein export by interacting with FlhAC to activate the Na+-driven export engine. The proposed mechanism helps to explain how bacteria can maintain flagellar protein exp...

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Autores principales: Tohru Minamino, Miki Kinoshita, Yusuke V. Morimoto, Keiichi Namba
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/de61e2e8ffbe45fdaa035216e7c70a89
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Sumario:Minamino et al. report that the bacterial FlgN chaperone acts as a switch to activate a backup mechanism for H+-coupled flagellar protein export by interacting with FlhAC to activate the Na+-driven export engine. The proposed mechanism helps to explain how bacteria can maintain flagellar protein export when the ATPase complex export machinery becomes non-functional.