CryoEM structure of the type IVa pilus secretin required for natural competence in Vibrio cholerae

In Vibrio cholerae, a type IVa pilus (T4aP) binds to exogenous DNA, and threads this DNA through the outer membrane secretin, PilQ. Here authors present the cryoEM structure of PilQ from native V. cholerae cells and design a series of mutants to reversibly regulate VcPilQ gate dynamics.

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Autores principales:	Sara J. Weaver, Davi R. Ortega, Matthew H. Sazinsky, Triana N. Dalia, Ankur B. Dalia, Grant J. Jensen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/de636c4c0f2848799bcd97430b5b4375
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spelling	oai:doaj.org-article:de636c4c0f2848799bcd97430b5b43752021-12-02T18:37:18ZCryoEM structure of the type IVa pilus secretin required for natural competence in Vibrio cholerae10.1038/s41467-020-18866-y2041-1723https://doaj.org/article/de636c4c0f2848799bcd97430b5b43752020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18866-yhttps://doaj.org/toc/2041-1723In Vibrio cholerae, a type IVa pilus (T4aP) binds to exogenous DNA, and threads this DNA through the outer membrane secretin, PilQ. Here authors present the cryoEM structure of PilQ from native V. cholerae cells and design a series of mutants to reversibly regulate VcPilQ gate dynamics.Sara J. WeaverDavi R. OrtegaMatthew H. SazinskyTriana N. DaliaAnkur B. DaliaGrant J. JensenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sara J. Weaver Davi R. Ortega Matthew H. Sazinsky Triana N. Dalia Ankur B. Dalia Grant J. Jensen CryoEM structure of the type IVa pilus secretin required for natural competence in Vibrio cholerae
description	In Vibrio cholerae, a type IVa pilus (T4aP) binds to exogenous DNA, and threads this DNA through the outer membrane secretin, PilQ. Here authors present the cryoEM structure of PilQ from native V. cholerae cells and design a series of mutants to reversibly regulate VcPilQ gate dynamics.
format	article
author	Sara J. Weaver Davi R. Ortega Matthew H. Sazinsky Triana N. Dalia Ankur B. Dalia Grant J. Jensen
author_facet	Sara J. Weaver Davi R. Ortega Matthew H. Sazinsky Triana N. Dalia Ankur B. Dalia Grant J. Jensen
author_sort	Sara J. Weaver
title	CryoEM structure of the type IVa pilus secretin required for natural competence in Vibrio cholerae
title_short	CryoEM structure of the type IVa pilus secretin required for natural competence in Vibrio cholerae
title_full	CryoEM structure of the type IVa pilus secretin required for natural competence in Vibrio cholerae
title_fullStr	CryoEM structure of the type IVa pilus secretin required for natural competence in Vibrio cholerae
title_full_unstemmed	CryoEM structure of the type IVa pilus secretin required for natural competence in Vibrio cholerae
title_sort	cryoem structure of the type iva pilus secretin required for natural competence in vibrio cholerae
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/de636c4c0f2848799bcd97430b5b4375
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CryoEM structure of the type IVa pilus secretin required for natural competence in Vibrio cholerae

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