A Human IRE1 Inhibitor Blocks the Unfolded Protein Response in the Pathogenic Fungus <named-content content-type="genus-species">Aspergillus fumigatus</named-content> and Suggests Noncanonical Functions within the Pathway

A Human IRE1 Inhibitor Blocks the Unfolded Protein Response in the Pathogenic Fungus <named-content content-type="genus-species">Aspergillus fumigatus</named-content> and Suggests Noncanonical Functions within the Pathway

ABSTRACT The unfolded protein response (UPR) is a signaling network that maintains homeostasis of the endoplasmic reticulum (ER). In the human-pathogenic fungus Aspergillus fumigatus, the UPR is initiated by activation of an endoribonuclease (RNase) domain in the ER transmembrane stress sensor IreA,...

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Autores principales: José P. Guirao-Abad, Martin Weichert, Aaron Albee, Katie Deck, David S. Askew
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2020
Materias:
A. fumigatus
UPR
4μ8C
ER stress
IRE1
IreA
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/de64c7c49fec4315af7cd50de0ba93da
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