A Human IRE1 Inhibitor Blocks the Unfolded Protein Response in the Pathogenic Fungus <named-content content-type="genus-species">Aspergillus fumigatus</named-content> and Suggests Noncanonical Functions within the Pathway
ABSTRACT The unfolded protein response (UPR) is a signaling network that maintains homeostasis of the endoplasmic reticulum (ER). In the human-pathogenic fungus Aspergillus fumigatus, the UPR is initiated by activation of an endoribonuclease (RNase) domain in the ER transmembrane stress sensor IreA,...
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| Main Authors: | , , , , |
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| Format: | article |
| Language: | EN |
| Published: |
American Society for Microbiology
2020
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| Subjects: | |
| Online Access: | https://doaj.org/article/de64c7c49fec4315af7cd50de0ba93da |
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