A multicenter evaluation of ocular surface disease prevalence in patients with glaucoma

Julian Garcia-Feijoo1, Juan Roberto Sampaolesi21Hospital Cl&iacute;nico San Carlos, Instituto de Investigaciones Oftalm&oacute;logicas Ram&oacute;n Castroviejo, Universidad Complutense, Red Tem&aacute;tica de Investigaci&oacute;n Cooperativa ISCIII, Spain; 2Ce...

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Autores principales:	Garcia-Fejioo J, Sampaolesi JR
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/de64cc8b94b94c49a3b551b35eaad284
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spelling	oai:doaj.org-article:de64cc8b94b94c49a3b551b35eaad2842021-12-02T09:07:03ZA multicenter evaluation of ocular surface disease prevalence in patients with glaucoma1177-54671177-5483https://doaj.org/article/de64cc8b94b94c49a3b551b35eaad2842012-03-01T00:00:00Zhttp://www.dovepress.com/a-multicenter-evaluation-of-ocular-surface-disease-prevalence-in-patie-a9538https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Julian Garcia-Feijoo1, Juan Roberto Sampaolesi21Hospital Cl&iacute;nico San Carlos, Instituto de Investigaciones Oftalm&oacute;logicas Ram&oacute;n Castroviejo, Universidad Complutense, Red Tem&aacute;tica de Investigaci&oacute;n Cooperativa ISCIII, Spain; 2Centro Oftalmol&oacute;gico Sampaolesi, Buenos Aires, ArgentinaBackground: Glaucoma can be associated with an increase in the occurrence of ocular surface disease (OSD) symptoms. The objective of this study was to examine the prevalence of ocular surface complaints in patients with glaucoma who used topical intraocular pressure (IOP)-lowering therapies.Methods: In this multicenter, international, noninterventional study, adults with glaucoma or ocular hypertension who were using 1 or more topical IOP-lowering medications completed the Ocular Surface Disease Index (OSDI) questionnaire during a regularly scheduled clinic visit. OSDI scores (ranging from 0 to 100) were calculated for each patient. An OSDI score &ge;13 indicated a clinically relevant presence of OSD.Results: Of the 448 patients who were evaluated, 53.3% were women, 61.6% had a diagnosis of primary open-angle glaucoma, and the mean age was 63 years. The overall OSD prevalence rate in the evaluable population was 59.2%, with 25.7%, 13.2%, and 20.3% of the patients reporting mild, moderate, or severe OSD symptoms, respectively. Patients with glaucoma diagnoses of less than 6 years had a significantly lower mean OSDI score relative to patients with glaucoma diagnoses of 6 years or more (18 [mild OSD] versus 23 [moderate OSD], respectively; P = 0.03). As the number of IOP-lowering treatments increased from one or two medications to three or four medications, the mean OSDI score increased from mild to moderate, though the difference in scores was not statistically significant (P = 0.15).Conclusions: OSD was highly prevalent in this population of glaucoma patients who were using IOP-lowering medications. Longer duration since diagnosis was significantly correlated with worsening of OSD symptoms. Increases in the number of medications applied also showed a clinically relevant increase in OSD symptom severity.Keywords: OSDI, correlation, time since diagnosis, number of medicationsGarcia-Fejioo JSampaolesi JRDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2012, Iss default, Pp 441-446 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Garcia-Fejioo J Sampaolesi JR A multicenter evaluation of ocular surface disease prevalence in patients with glaucoma
description	Julian Garcia-Feijoo1, Juan Roberto Sampaolesi21Hospital Cl&iacute;nico San Carlos, Instituto de Investigaciones Oftalm&oacute;logicas Ram&oacute;n Castroviejo, Universidad Complutense, Red Tem&aacute;tica de Investigaci&oacute;n Cooperativa ISCIII, Spain; 2Centro Oftalmol&oacute;gico Sampaolesi, Buenos Aires, ArgentinaBackground: Glaucoma can be associated with an increase in the occurrence of ocular surface disease (OSD) symptoms. The objective of this study was to examine the prevalence of ocular surface complaints in patients with glaucoma who used topical intraocular pressure (IOP)-lowering therapies.Methods: In this multicenter, international, noninterventional study, adults with glaucoma or ocular hypertension who were using 1 or more topical IOP-lowering medications completed the Ocular Surface Disease Index (OSDI) questionnaire during a regularly scheduled clinic visit. OSDI scores (ranging from 0 to 100) were calculated for each patient. An OSDI score &ge;13 indicated a clinically relevant presence of OSD.Results: Of the 448 patients who were evaluated, 53.3% were women, 61.6% had a diagnosis of primary open-angle glaucoma, and the mean age was 63 years. The overall OSD prevalence rate in the evaluable population was 59.2%, with 25.7%, 13.2%, and 20.3% of the patients reporting mild, moderate, or severe OSD symptoms, respectively. Patients with glaucoma diagnoses of less than 6 years had a significantly lower mean OSDI score relative to patients with glaucoma diagnoses of 6 years or more (18 [mild OSD] versus 23 [moderate OSD], respectively; P = 0.03). As the number of IOP-lowering treatments increased from one or two medications to three or four medications, the mean OSDI score increased from mild to moderate, though the difference in scores was not statistically significant (P = 0.15).Conclusions: OSD was highly prevalent in this population of glaucoma patients who were using IOP-lowering medications. Longer duration since diagnosis was significantly correlated with worsening of OSD symptoms. Increases in the number of medications applied also showed a clinically relevant increase in OSD symptom severity.Keywords: OSDI, correlation, time since diagnosis, number of medications
format	article
author	Garcia-Fejioo J Sampaolesi JR
author_facet	Garcia-Fejioo J Sampaolesi JR
author_sort	Garcia-Fejioo J
title	A multicenter evaluation of ocular surface disease prevalence in patients with glaucoma
title_short	A multicenter evaluation of ocular surface disease prevalence in patients with glaucoma
title_full	A multicenter evaluation of ocular surface disease prevalence in patients with glaucoma
title_fullStr	A multicenter evaluation of ocular surface disease prevalence in patients with glaucoma
title_full_unstemmed	A multicenter evaluation of ocular surface disease prevalence in patients with glaucoma
title_sort	multicenter evaluation of ocular surface disease prevalence in patients with glaucoma
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/de64cc8b94b94c49a3b551b35eaad284
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A multicenter evaluation of ocular surface disease prevalence in patients with glaucoma

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