The Wnt antagonist sFRP1 as a favorable prognosticator in human biliary tract carcinoma.

Inactivation of Secreted Frizzled-Related Protein-1 (SFRP1) and overexpression of β-catenin play important roles in the development and progression of a wide range of malignancies. We sought to determine whether the expression of SFRP1 and β-catenin correlates with clinicopathologic parameters in hu...

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Autores principales:	Pengcheng Kang, Ming Wan, Peng Huang, Chunlong Li, Zhidong Wang, Xiangyu Zhong, Zhanliang Hu, Sheng Tai, Yunfu Cui
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/de6598ecd7b549eebce20affc34d513f
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spelling	oai:doaj.org-article:de6598ecd7b549eebce20affc34d513f2021-11-18T08:30:07ZThe Wnt antagonist sFRP1 as a favorable prognosticator in human biliary tract carcinoma.1932-620310.1371/journal.pone.0090308https://doaj.org/article/de6598ecd7b549eebce20affc34d513f2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24594839/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Inactivation of Secreted Frizzled-Related Protein-1 (SFRP1) and overexpression of β-catenin play important roles in the development and progression of a wide range of malignancies. We sought to determine whether the expression of SFRP1 and β-catenin correlates with clinicopathologic parameters in human biliary tract cancer (BTC) and to evaluate the potential roles of these proteins as prognostic indicators. The expression of SFRP1 and β-catenin in 78 patients with BTC and 36 control patients as investigated by immunohistochemistry. A wide variety of statistical parameters were assessed to determine the association between these proteins and the occurrence, clinical features, and overall survival rate in BTC.SFRP1 and β-catenin had an inverse correlation (r = -0.636, P<0.0001) as assessed by Spearman rank analysis, with 52 (66.7%) of the BTC samples negative for SFRP1 expression and 53 (68.0%) positive for β-catenin expression. Expression of each protein was associated with the histological type and lymph node invasion of BTC. A significantly poorer overall survival rate was observed for patients with low SFRP1 expression (P<0.0001) or high β-catenin expression (P = 0.007). SFRP1 expression (P<0.0001), β-catenin expression (P<0.01) and histological type (P<0.01) were correlated with overall survival rate as assessed by univariate analysis; while multivariate analysis suggested that SFRP1 (hazard ratio, 10.514; 95% confidence intervals, 2.381-39.048; P<0.0001) may serve as an independent prognostic factor for BTC. Collectively, these results demonstrate that SFRP1 is a favorable prognostic factor for human BTC and that its expression inversely correlates with that of β-catenin.Pengcheng KangMing WanPeng HuangChunlong LiZhidong WangXiangyu ZhongZhanliang HuSheng TaiYunfu CuiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 3, p e90308 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pengcheng Kang Ming Wan Peng Huang Chunlong Li Zhidong Wang Xiangyu Zhong Zhanliang Hu Sheng Tai Yunfu Cui The Wnt antagonist sFRP1 as a favorable prognosticator in human biliary tract carcinoma.
description	Inactivation of Secreted Frizzled-Related Protein-1 (SFRP1) and overexpression of β-catenin play important roles in the development and progression of a wide range of malignancies. We sought to determine whether the expression of SFRP1 and β-catenin correlates with clinicopathologic parameters in human biliary tract cancer (BTC) and to evaluate the potential roles of these proteins as prognostic indicators. The expression of SFRP1 and β-catenin in 78 patients with BTC and 36 control patients as investigated by immunohistochemistry. A wide variety of statistical parameters were assessed to determine the association between these proteins and the occurrence, clinical features, and overall survival rate in BTC.SFRP1 and β-catenin had an inverse correlation (r = -0.636, P<0.0001) as assessed by Spearman rank analysis, with 52 (66.7%) of the BTC samples negative for SFRP1 expression and 53 (68.0%) positive for β-catenin expression. Expression of each protein was associated with the histological type and lymph node invasion of BTC. A significantly poorer overall survival rate was observed for patients with low SFRP1 expression (P<0.0001) or high β-catenin expression (P = 0.007). SFRP1 expression (P<0.0001), β-catenin expression (P<0.01) and histological type (P<0.01) were correlated with overall survival rate as assessed by univariate analysis; while multivariate analysis suggested that SFRP1 (hazard ratio, 10.514; 95% confidence intervals, 2.381-39.048; P<0.0001) may serve as an independent prognostic factor for BTC. Collectively, these results demonstrate that SFRP1 is a favorable prognostic factor for human BTC and that its expression inversely correlates with that of β-catenin.
format	article
author	Pengcheng Kang Ming Wan Peng Huang Chunlong Li Zhidong Wang Xiangyu Zhong Zhanliang Hu Sheng Tai Yunfu Cui
author_facet	Pengcheng Kang Ming Wan Peng Huang Chunlong Li Zhidong Wang Xiangyu Zhong Zhanliang Hu Sheng Tai Yunfu Cui
author_sort	Pengcheng Kang
title	The Wnt antagonist sFRP1 as a favorable prognosticator in human biliary tract carcinoma.
title_short	The Wnt antagonist sFRP1 as a favorable prognosticator in human biliary tract carcinoma.
title_full	The Wnt antagonist sFRP1 as a favorable prognosticator in human biliary tract carcinoma.
title_fullStr	The Wnt antagonist sFRP1 as a favorable prognosticator in human biliary tract carcinoma.
title_full_unstemmed	The Wnt antagonist sFRP1 as a favorable prognosticator in human biliary tract carcinoma.
title_sort	wnt antagonist sfrp1 as a favorable prognosticator in human biliary tract carcinoma.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/de6598ecd7b549eebce20affc34d513f
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The Wnt antagonist sFRP1 as a favorable prognosticator in human biliary tract carcinoma.

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