Pan-cancer analysis of RNA expression of ANGIOTENSIN-I-CONVERTING ENZYME 2 reveals high variability and possible impact on COVID-19 clinical outcomes

Abstract Patients with cancer demonstrate particularly poor outcomes from COVID-19. To provide information essential for understanding the biologic underpinnings of this association, we analyzed whole-transcriptome RNA expression data obtained from a large cohort of cancer patients to characterize e...

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Autores principales:	Andrew Elliott, Michelle Saul, Jia Zeng, John L. Marshall, Edward S. Kim, Misako Nagasaka, Heinz-Josef Lenz, Lee Schwartzberg, David Spetzler, Jim Abraham, Joanne Xiu, Phillip Stafford, W. Michael Korn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/de659d81a8a243fe8527f66b921f70ed
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spelling	oai:doaj.org-article:de659d81a8a243fe8527f66b921f70ed2021-12-02T11:35:53ZPan-cancer analysis of RNA expression of ANGIOTENSIN-I-CONVERTING ENZYME 2 reveals high variability and possible impact on COVID-19 clinical outcomes10.1038/s41598-021-84731-72045-2322https://doaj.org/article/de659d81a8a243fe8527f66b921f70ed2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84731-7https://doaj.org/toc/2045-2322Abstract Patients with cancer demonstrate particularly poor outcomes from COVID-19. To provide information essential for understanding the biologic underpinnings of this association, we analyzed whole-transcriptome RNA expression data obtained from a large cohort of cancer patients to characterize expression of ACE2, TMPRSS2, and other proteases that are involved in viral attachment to and entry into target cells. We find substantial variability of expression of these factors across tumor types and identify subpopulations expressing ACE2 at very high levels. In some tumor types, especially in gastrointestinal cancers, expression of ACE2 and TMPRSS2 is highly correlated. Furthermore, we found infiltration with T-cell and natural killer (NK) cell infiltration to be particularly pronounced in ACE2-high tumors. These findings suggest that subsets of cancer patients exist with gene expression profiles that may be associated with heightened susceptibility to SARS-CoV-2 infection, in whom malignant tumors function as viral reservoir and possibly promote the frequently detrimental hyper-immune response in patients infected with this virus.Andrew ElliottMichelle SaulJia ZengJohn L. MarshallEdward S. KimMisako NagasakaHeinz-Josef LenzLee SchwartzbergDavid SpetzlerJim AbrahamJoanne XiuPhillip StaffordW. Michael KornNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Andrew Elliott Michelle Saul Jia Zeng John L. Marshall Edward S. Kim Misako Nagasaka Heinz-Josef Lenz Lee Schwartzberg David Spetzler Jim Abraham Joanne Xiu Phillip Stafford W. Michael Korn Pan-cancer analysis of RNA expression of ANGIOTENSIN-I-CONVERTING ENZYME 2 reveals high variability and possible impact on COVID-19 clinical outcomes
description	Abstract Patients with cancer demonstrate particularly poor outcomes from COVID-19. To provide information essential for understanding the biologic underpinnings of this association, we analyzed whole-transcriptome RNA expression data obtained from a large cohort of cancer patients to characterize expression of ACE2, TMPRSS2, and other proteases that are involved in viral attachment to and entry into target cells. We find substantial variability of expression of these factors across tumor types and identify subpopulations expressing ACE2 at very high levels. In some tumor types, especially in gastrointestinal cancers, expression of ACE2 and TMPRSS2 is highly correlated. Furthermore, we found infiltration with T-cell and natural killer (NK) cell infiltration to be particularly pronounced in ACE2-high tumors. These findings suggest that subsets of cancer patients exist with gene expression profiles that may be associated with heightened susceptibility to SARS-CoV-2 infection, in whom malignant tumors function as viral reservoir and possibly promote the frequently detrimental hyper-immune response in patients infected with this virus.
format	article
author	Andrew Elliott Michelle Saul Jia Zeng John L. Marshall Edward S. Kim Misako Nagasaka Heinz-Josef Lenz Lee Schwartzberg David Spetzler Jim Abraham Joanne Xiu Phillip Stafford W. Michael Korn
author_facet	Andrew Elliott Michelle Saul Jia Zeng John L. Marshall Edward S. Kim Misako Nagasaka Heinz-Josef Lenz Lee Schwartzberg David Spetzler Jim Abraham Joanne Xiu Phillip Stafford W. Michael Korn
author_sort	Andrew Elliott
title	Pan-cancer analysis of RNA expression of ANGIOTENSIN-I-CONVERTING ENZYME 2 reveals high variability and possible impact on COVID-19 clinical outcomes
title_short	Pan-cancer analysis of RNA expression of ANGIOTENSIN-I-CONVERTING ENZYME 2 reveals high variability and possible impact on COVID-19 clinical outcomes
title_full	Pan-cancer analysis of RNA expression of ANGIOTENSIN-I-CONVERTING ENZYME 2 reveals high variability and possible impact on COVID-19 clinical outcomes
title_fullStr	Pan-cancer analysis of RNA expression of ANGIOTENSIN-I-CONVERTING ENZYME 2 reveals high variability and possible impact on COVID-19 clinical outcomes
title_full_unstemmed	Pan-cancer analysis of RNA expression of ANGIOTENSIN-I-CONVERTING ENZYME 2 reveals high variability and possible impact on COVID-19 clinical outcomes
title_sort	pan-cancer analysis of rna expression of angiotensin-i-converting enzyme 2 reveals high variability and possible impact on covid-19 clinical outcomes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/de659d81a8a243fe8527f66b921f70ed
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Pan-cancer analysis of RNA expression of ANGIOTENSIN-I-CONVERTING ENZYME 2 reveals high variability and possible impact on COVID-19 clinical outcomes

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