Lnc-TALC promotes O6-methylguanine-DNA methyltransferase expression via regulating the c-Met pathway by competitively binding with miR-20b-3p

Temozolomide resistance in glioblastoma is associated with MGMT overexpression. Here, the authors identify a lncRNA that is a competitive endogenous RNA for miR-20b-3p, which causes c-Met activation to modulate acetylation of histone H3 on MGMT promoter through Stat3/p300 complex to increase MGMT ex...

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Autores principales:	Pengfei Wu, Jinquan Cai, Qun Chen, Bo Han, Xiangqi Meng, Yansheng Li, Ziwei Li, Ruijia Wang, Lin Lin, Chunbin Duan, Chunsheng Kang, Chuanlu Jiang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/de66e2e963cb4ae19f9786f44c1dfc95
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:de66e2e963cb4ae19f9786f44c1dfc952021-12-02T14:39:56ZLnc-TALC promotes O6-methylguanine-DNA methyltransferase expression via regulating the c-Met pathway by competitively binding with miR-20b-3p10.1038/s41467-019-10025-22041-1723https://doaj.org/article/de66e2e963cb4ae19f9786f44c1dfc952019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10025-2https://doaj.org/toc/2041-1723Temozolomide resistance in glioblastoma is associated with MGMT overexpression. Here, the authors identify a lncRNA that is a competitive endogenous RNA for miR-20b-3p, which causes c-Met activation to modulate acetylation of histone H3 on MGMT promoter through Stat3/p300 complex to increase MGMT expression and temozolomide resistance.Pengfei WuJinquan CaiQun ChenBo HanXiangqi MengYansheng LiZiwei LiRuijia WangLin LinChunbin DuanChunsheng KangChuanlu JiangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pengfei Wu Jinquan Cai Qun Chen Bo Han Xiangqi Meng Yansheng Li Ziwei Li Ruijia Wang Lin Lin Chunbin Duan Chunsheng Kang Chuanlu Jiang Lnc-TALC promotes O6-methylguanine-DNA methyltransferase expression via regulating the c-Met pathway by competitively binding with miR-20b-3p
description	Temozolomide resistance in glioblastoma is associated with MGMT overexpression. Here, the authors identify a lncRNA that is a competitive endogenous RNA for miR-20b-3p, which causes c-Met activation to modulate acetylation of histone H3 on MGMT promoter through Stat3/p300 complex to increase MGMT expression and temozolomide resistance.
format	article
author	Pengfei Wu Jinquan Cai Qun Chen Bo Han Xiangqi Meng Yansheng Li Ziwei Li Ruijia Wang Lin Lin Chunbin Duan Chunsheng Kang Chuanlu Jiang
author_facet	Pengfei Wu Jinquan Cai Qun Chen Bo Han Xiangqi Meng Yansheng Li Ziwei Li Ruijia Wang Lin Lin Chunbin Duan Chunsheng Kang Chuanlu Jiang
author_sort	Pengfei Wu
title	Lnc-TALC promotes O6-methylguanine-DNA methyltransferase expression via regulating the c-Met pathway by competitively binding with miR-20b-3p
title_short	Lnc-TALC promotes O6-methylguanine-DNA methyltransferase expression via regulating the c-Met pathway by competitively binding with miR-20b-3p
title_full	Lnc-TALC promotes O6-methylguanine-DNA methyltransferase expression via regulating the c-Met pathway by competitively binding with miR-20b-3p
title_fullStr	Lnc-TALC promotes O6-methylguanine-DNA methyltransferase expression via regulating the c-Met pathway by competitively binding with miR-20b-3p
title_full_unstemmed	Lnc-TALC promotes O6-methylguanine-DNA methyltransferase expression via regulating the c-Met pathway by competitively binding with miR-20b-3p
title_sort	lnc-talc promotes o6-methylguanine-dna methyltransferase expression via regulating the c-met pathway by competitively binding with mir-20b-3p
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/de66e2e963cb4ae19f9786f44c1dfc95
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Lnc-TALC promotes O6-methylguanine-DNA methyltransferase expression via regulating the c-Met pathway by competitively binding with miR-20b-3p

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