Lnc-TALC promotes O6-methylguanine-DNA methyltransferase expression via regulating the c-Met pathway by competitively binding with miR-20b-3p

Lnc-TALC promotes O6-methylguanine-DNA methyltransferase expression via regulating the c-Met pathway by competitively binding with miR-20b-3p

Temozolomide resistance in glioblastoma is associated with MGMT overexpression. Here, the authors identify a lncRNA that is a competitive endogenous RNA for miR-20b-3p, which causes c-Met activation to modulate acetylation of histone H3 on MGMT promoter through Stat3/p300 complex to increase MGMT ex...

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Autores principales: Pengfei Wu, Jinquan Cai, Qun Chen, Bo Han, Xiangqi Meng, Yansheng Li, Ziwei Li, Ruijia Wang, Lin Lin, Chunbin Duan, Chunsheng Kang, Chuanlu Jiang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/de66e2e963cb4ae19f9786f44c1dfc95
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