Validation of abnormal glucose metabolism associated with Parkinson’s disease in Chinese participants based on 18F-fluorodeoxyglucose positron emission tomography imaging

Validation of abnormal glucose metabolism associated with Parkinson’s disease in Chinese participants based on 18F-fluorodeoxyglucose positron emission tomography imaging

Rongbing Jin,1,* Jingjie Ge,2,* Ping Wu,2 Jiaying Lu,2 Huiwei Zhang,2 Jian Wang,3 Jianjun Wu,3 Xianhua Han,2 Weishan Zhang,2 Chuantao Zuo2,4 1Department of Nuclear Medicine, Daping Hospital, Army Medical University, Chongqing 400042, China; 2PET Center, Huashan Hospital, Fudan University, Shanghai...

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Autores principales: Jin R, Ge J, Wu P, Lu J, Zhang H, Wang J, Wu J, Han X, Zhang W, Zuo C
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2018
Materias:
movement disorders
Parkinsonism
disease diagnosis
positron emission tomography
neuroimaging marker
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/de67a45d3d384432aa76423d573fe29a
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spelling oai:doaj.org-article:de67a45d3d384432aa76423d573fe29a2021-12-02T09:35:58ZValidation of abnormal glucose metabolism associated with Parkinson’s disease in Chinese participants based on 18F-fluorodeoxyglucose positron emission tomography imaging1178-2021https://doaj.org/article/de67a45d3d384432aa76423d573fe29a2018-08-01T00:00:00Zhttps://www.dovepress.com/validation-of-abnormal-glucose-metabolism-associated-with-parkinsons-d-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Rongbing Jin,1,* Jingjie Ge,2,* Ping Wu,2 Jiaying Lu,2 Huiwei Zhang,2 Jian Wang,3 Jianjun Wu,3 Xianhua Han,2 Weishan Zhang,2 Chuantao Zuo2,4 1Department of Nuclear Medicine, Daping Hospital, Army Medical University, Chongqing 400042, China; 2PET Center, Huashan Hospital, Fudan University, Shanghai 200235, China; 3Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, China; 4Institute of Functional and Molecular Medical Imaging, Fudan University, Shanghai 200433, China *These authors contributed equally to this work Purpose: We previously identified disease-related cerebral metabolic characteristics associated with Parkinson’s disease (PD) in the Chinese population using 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) imaging. The present study aims to assess data reproducibility and robustness of the metabolic activity characteristics across independent cohorts. Patients and methods: Forty-eight patients with PD and 48 healthy controls from Chongqing district, in addition to 33 patients with PD and 33 healthy controls from Shanghai district were recruited. Each subject underwent brain 18F-FDG PET/CT imaging in a resting state. Based on the brain images, differences between the groups and PD-related cerebral metabolic activities were graphically and quantitatively evaluated. Results: Both PD patient cohorts exhibited analogous cerebral patterns characterized by metabolic increase in the putamen, globus pallidus, thalamus, pons, sensorimotor cortex and cerebellum, along with metabolic decrease in parieto-occipital areas. Additionally, the metabolic pattern was highly indicative of the disease, with a significant elevation in PD patients compared with healthy controls (p<0.001) in both the derivation (Shanghai) and validation (Chongqing) cohorts. Conclusion: This dual-center study demonstrated the high comparability and reproducibility of PD-related cerebral metabolic activity patterns across independent Chinese cohorts and may serve as an objective diagnostic marker for the disease. Keywords: movement disorders, parkinsonism, disease diagnosis, positron emission tomography, neuroimaging marker, Parkinson’s diseaseJin RGe JWu PLu JZhang HWang JWu JHan XZhang WZuo CDove Medical Pressarticlemovement disordersParkinsonismdisease diagnosispositron emission tomographyneuroimaging markerNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 1981-1989 (2018)
institution DOAJ
collection DOAJ
language EN
topic movement disorders
Parkinsonism
disease diagnosis
positron emission tomography
neuroimaging marker
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle movement disorders
Parkinsonism
disease diagnosis
positron emission tomography
neuroimaging marker
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Jin R
Ge J
Wu P
Lu J
Zhang H
Wang J
Wu J
Han X
Zhang W
Zuo C
Validation of abnormal glucose metabolism associated with Parkinson’s disease in Chinese participants based on 18F-fluorodeoxyglucose positron emission tomography imaging
description Rongbing Jin,1,* Jingjie Ge,2,* Ping Wu,2 Jiaying Lu,2 Huiwei Zhang,2 Jian Wang,3 Jianjun Wu,3 Xianhua Han,2 Weishan Zhang,2 Chuantao Zuo2,4 1Department of Nuclear Medicine, Daping Hospital, Army Medical University, Chongqing 400042, China; 2PET Center, Huashan Hospital, Fudan University, Shanghai 200235, China; 3Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, China; 4Institute of Functional and Molecular Medical Imaging, Fudan University, Shanghai 200433, China *These authors contributed equally to this work Purpose: We previously identified disease-related cerebral metabolic characteristics associated with Parkinson’s disease (PD) in the Chinese population using 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) imaging. The present study aims to assess data reproducibility and robustness of the metabolic activity characteristics across independent cohorts. Patients and methods: Forty-eight patients with PD and 48 healthy controls from Chongqing district, in addition to 33 patients with PD and 33 healthy controls from Shanghai district were recruited. Each subject underwent brain 18F-FDG PET/CT imaging in a resting state. Based on the brain images, differences between the groups and PD-related cerebral metabolic activities were graphically and quantitatively evaluated. Results: Both PD patient cohorts exhibited analogous cerebral patterns characterized by metabolic increase in the putamen, globus pallidus, thalamus, pons, sensorimotor cortex and cerebellum, along with metabolic decrease in parieto-occipital areas. Additionally, the metabolic pattern was highly indicative of the disease, with a significant elevation in PD patients compared with healthy controls (p<0.001) in both the derivation (Shanghai) and validation (Chongqing) cohorts. Conclusion: This dual-center study demonstrated the high comparability and reproducibility of PD-related cerebral metabolic activity patterns across independent Chinese cohorts and may serve as an objective diagnostic marker for the disease. Keywords: movement disorders, parkinsonism, disease diagnosis, positron emission tomography, neuroimaging marker, Parkinson’s disease
format article
author Jin R
Ge J
Wu P
Lu J
Zhang H
Wang J
Wu J
Han X
Zhang W
Zuo C
author_facet Jin R
Ge J
Wu P
Lu J
Zhang H
Wang J
Wu J
Han X
Zhang W
Zuo C
author_sort Jin R
title Validation of abnormal glucose metabolism associated with Parkinson’s disease in Chinese participants based on 18F-fluorodeoxyglucose positron emission tomography imaging
title_short Validation of abnormal glucose metabolism associated with Parkinson’s disease in Chinese participants based on 18F-fluorodeoxyglucose positron emission tomography imaging
title_full Validation of abnormal glucose metabolism associated with Parkinson’s disease in Chinese participants based on 18F-fluorodeoxyglucose positron emission tomography imaging
title_fullStr Validation of abnormal glucose metabolism associated with Parkinson’s disease in Chinese participants based on 18F-fluorodeoxyglucose positron emission tomography imaging
title_full_unstemmed Validation of abnormal glucose metabolism associated with Parkinson’s disease in Chinese participants based on 18F-fluorodeoxyglucose positron emission tomography imaging
title_sort validation of abnormal glucose metabolism associated with parkinson’s disease in chinese participants based on 18f-fluorodeoxyglucose positron emission tomography imaging
publisher Dove Medical Press
publishDate 2018
url https://doaj.org/article/de67a45d3d384432aa76423d573fe29a
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