IMMUNOLOGICAL PARAMETERS IN PATIENTS WITH MONOINFECTION BY HUMAN PAPILLOMAVIRUS AND IN PATIENTS CO-INFECTED BY PAPILLOMAVIRUS AND UROGENITAL PATHOGENS

Aim of this study was to investigate the characteristics of cellular and humoral immunity and functional activity of neutrophilic granulocytes in women with monoinfection by human papillomavirus and combination of human papillomavirus (HPVI) and urogenital pathogens (UGI). It was established that mo...

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Autores principales:	A. A. Savchenko, V. B. Tshai, K. Y. Kruglova, A. G. Borisov
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2014
Materias:	lymphocytes neutrophils monoinfection co-infection chemiluminescent activity Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/de68bed519974bdbb4644483c67ba5aa
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spelling	oai:doaj.org-article:de68bed519974bdbb4644483c67ba5aa2021-11-22T07:09:47ZIMMUNOLOGICAL PARAMETERS IN PATIENTS WITH MONOINFECTION BY HUMAN PAPILLOMAVIRUS AND IN PATIENTS CO-INFECTED BY PAPILLOMAVIRUS AND UROGENITAL PATHOGENS2220-76192313-739810.15789/2220-7619-2014-3-241-248https://doaj.org/article/de68bed519974bdbb4644483c67ba5aa2014-08-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/183https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Aim of this study was to investigate the characteristics of cellular and humoral immunity and functional activity of neutrophilic granulocytes in women with monoinfection by human papillomavirus and combination of human papillomavirus (HPVI) and urogenital pathogens (UGI). It was established that more serious disorders in the immune system in women were revealed in case of mixed HPVI and UGI in compare with case of monoinfection by human papillomavirus. Only in patients with combined HPVI and UGI the content of total lymphocytes, T-cells and cytotoxic T lymphocytes was reduced. In patients with combined HPVI and UGI the humoral immunity was characterised by increased concentration of IgM, its level of relative synthesis and content of circulating immune complexes. Independently of the infection type in women the reduction of CD4+ lymphocytes, NK-cells, increased number of γδТ-lymphocytes, as well as increase the functional activity of blood neutrophils have been detected. However, in case of combined HPVI and UGI an inhibitory effect on the reserve capacities of phagocytic cells was revealed.A. A. SavchenkoV. B. TshaiK. Y. KruglovaA. G. BorisovSankt-Peterburg : NIIÈM imeni Pasteraarticlelymphocytesneutrophilsmonoinfectionco-infectionchemiluminescent activityInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 4, Iss 3, Pp 241-248 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	lymphocytes neutrophils monoinfection co-infection chemiluminescent activity Infectious and parasitic diseases RC109-216
spellingShingle	lymphocytes neutrophils monoinfection co-infection chemiluminescent activity Infectious and parasitic diseases RC109-216 A. A. Savchenko V. B. Tshai K. Y. Kruglova A. G. Borisov IMMUNOLOGICAL PARAMETERS IN PATIENTS WITH MONOINFECTION BY HUMAN PAPILLOMAVIRUS AND IN PATIENTS CO-INFECTED BY PAPILLOMAVIRUS AND UROGENITAL PATHOGENS
description	Aim of this study was to investigate the characteristics of cellular and humoral immunity and functional activity of neutrophilic granulocytes in women with monoinfection by human papillomavirus and combination of human papillomavirus (HPVI) and urogenital pathogens (UGI). It was established that more serious disorders in the immune system in women were revealed in case of mixed HPVI and UGI in compare with case of monoinfection by human papillomavirus. Only in patients with combined HPVI and UGI the content of total lymphocytes, T-cells and cytotoxic T lymphocytes was reduced. In patients with combined HPVI and UGI the humoral immunity was characterised by increased concentration of IgM, its level of relative synthesis and content of circulating immune complexes. Independently of the infection type in women the reduction of CD4+ lymphocytes, NK-cells, increased number of γδТ-lymphocytes, as well as increase the functional activity of blood neutrophils have been detected. However, in case of combined HPVI and UGI an inhibitory effect on the reserve capacities of phagocytic cells was revealed.
format	article
author	A. A. Savchenko V. B. Tshai K. Y. Kruglova A. G. Borisov
author_facet	A. A. Savchenko V. B. Tshai K. Y. Kruglova A. G. Borisov
author_sort	A. A. Savchenko
title	IMMUNOLOGICAL PARAMETERS IN PATIENTS WITH MONOINFECTION BY HUMAN PAPILLOMAVIRUS AND IN PATIENTS CO-INFECTED BY PAPILLOMAVIRUS AND UROGENITAL PATHOGENS
title_short	IMMUNOLOGICAL PARAMETERS IN PATIENTS WITH MONOINFECTION BY HUMAN PAPILLOMAVIRUS AND IN PATIENTS CO-INFECTED BY PAPILLOMAVIRUS AND UROGENITAL PATHOGENS
title_full	IMMUNOLOGICAL PARAMETERS IN PATIENTS WITH MONOINFECTION BY HUMAN PAPILLOMAVIRUS AND IN PATIENTS CO-INFECTED BY PAPILLOMAVIRUS AND UROGENITAL PATHOGENS
title_fullStr	IMMUNOLOGICAL PARAMETERS IN PATIENTS WITH MONOINFECTION BY HUMAN PAPILLOMAVIRUS AND IN PATIENTS CO-INFECTED BY PAPILLOMAVIRUS AND UROGENITAL PATHOGENS
title_full_unstemmed	IMMUNOLOGICAL PARAMETERS IN PATIENTS WITH MONOINFECTION BY HUMAN PAPILLOMAVIRUS AND IN PATIENTS CO-INFECTED BY PAPILLOMAVIRUS AND UROGENITAL PATHOGENS
title_sort	immunological parameters in patients with monoinfection by human papillomavirus and in patients co-infected by papillomavirus and urogenital pathogens
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2014
url	https://doaj.org/article/de68bed519974bdbb4644483c67ba5aa
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IMMUNOLOGICAL PARAMETERS IN PATIENTS WITH MONOINFECTION BY HUMAN PAPILLOMAVIRUS AND IN PATIENTS CO-INFECTED BY PAPILLOMAVIRUS AND UROGENITAL PATHOGENS

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