Treatment of DM2 to-day. Should we change priorities? Conclusions based on recent clinical studies

This work is devoted to the analysis of results of recent clinical studies. It is argued that the absence of close association between normalized glycemiaand reduced incidence of cardiovascular disorders may be due to both relatively short duration of observations and possible effect of co-factors (...

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Autor principal:	Aleksey Vadimovich Zilov
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2009
Materias:	type 2 diabetes mellitus sulphonylurea derivatives randomized clinical studies glibenclamide Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/de6b76ba789e4d36a4c763e232a030f5
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id	oai:doaj.org-article:de6b76ba789e4d36a4c763e232a030f5
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spelling	oai:doaj.org-article:de6b76ba789e4d36a4c763e232a030f52021-11-14T09:00:14ZTreatment of DM2 to-day. Should we change priorities? Conclusions based on recent clinical studies2072-03512072-037810.14341/2072-0351-5716https://doaj.org/article/de6b76ba789e4d36a4c763e232a030f52009-12-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/5716https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378This work is devoted to the analysis of results of recent clinical studies. It is argued that the absence of close association between normalized glycemiaand reduced incidence of cardiovascular disorders may be due to both relatively short duration of observations and possible effect of co-factors (e.g. hypoglycemia/drug interaction, etc.). Some results suggest the necessity of multifactor approach to the treatment of DM2 especially for the reductionof cardiovascular mortality or prevention of vascular catastrophes. Sulphonylurea derivatives are regarded as putative risk factors of hypoglycemiaor vascular disorders. A number of publications are reviewed in which glibenclamide was shown to be safe in terms of risk of myocardial infarction.Aleksey Vadimovich ZilovEndocrinology Research Centrearticletype 2 diabetes mellitussulphonylurea derivativesrandomized clinical studiesglibenclamideNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 12, Iss 4, Pp 108-113 (2009)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	type 2 diabetes mellitus sulphonylurea derivatives randomized clinical studies glibenclamide Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	type 2 diabetes mellitus sulphonylurea derivatives randomized clinical studies glibenclamide Nutritional diseases. Deficiency diseases RC620-627 Aleksey Vadimovich Zilov Treatment of DM2 to-day. Should we change priorities? Conclusions based on recent clinical studies
description	This work is devoted to the analysis of results of recent clinical studies. It is argued that the absence of close association between normalized glycemiaand reduced incidence of cardiovascular disorders may be due to both relatively short duration of observations and possible effect of co-factors (e.g. hypoglycemia/drug interaction, etc.). Some results suggest the necessity of multifactor approach to the treatment of DM2 especially for the reductionof cardiovascular mortality or prevention of vascular catastrophes. Sulphonylurea derivatives are regarded as putative risk factors of hypoglycemiaor vascular disorders. A number of publications are reviewed in which glibenclamide was shown to be safe in terms of risk of myocardial infarction.
format	article
author	Aleksey Vadimovich Zilov
author_facet	Aleksey Vadimovich Zilov
author_sort	Aleksey Vadimovich Zilov
title	Treatment of DM2 to-day. Should we change priorities? Conclusions based on recent clinical studies
title_short	Treatment of DM2 to-day. Should we change priorities? Conclusions based on recent clinical studies
title_full	Treatment of DM2 to-day. Should we change priorities? Conclusions based on recent clinical studies
title_fullStr	Treatment of DM2 to-day. Should we change priorities? Conclusions based on recent clinical studies
title_full_unstemmed	Treatment of DM2 to-day. Should we change priorities? Conclusions based on recent clinical studies
title_sort	treatment of dm2 to-day. should we change priorities? conclusions based on recent clinical studies
publisher	Endocrinology Research Centre
publishDate	2009
url	https://doaj.org/article/de6b76ba789e4d36a4c763e232a030f5
work_keys_str_mv	AT alekseyvadimovichzilov treatmentofdm2todayshouldwechangeprioritiesconclusionsbasedonrecentclinicalstudies
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Treatment of DM2 to-day. Should we change priorities? Conclusions based on recent clinical studies

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