Chemotherapy-induced peripheral neuropathy: longitudinal analysis of predictors for postural control

Abstract Impaired postural control is often observed in response to neurotoxic chemotherapy. However, potential explanatory factors other than chemotherapy-induced peripheral neuropathy (CIPN) have not been adequately considered to date due to primarily cross-sectional study designs. Our objective w...

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Autores principales:	Jana Müller, Charlotte Kreutz, Steffen Ringhof, Maximilian Koeppel, Nikolaus Kleindienst, Georges Sam, Andreas Schneeweiss, Joachim Wiskemann, Markus Weiler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/de6be1994d5f4fb194f743552100ecce
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spelling	oai:doaj.org-article:de6be1994d5f4fb194f743552100ecce2021-12-02T14:16:07ZChemotherapy-induced peripheral neuropathy: longitudinal analysis of predictors for postural control10.1038/s41598-021-81902-42045-2322https://doaj.org/article/de6be1994d5f4fb194f743552100ecce2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81902-4https://doaj.org/toc/2045-2322Abstract Impaired postural control is often observed in response to neurotoxic chemotherapy. However, potential explanatory factors other than chemotherapy-induced peripheral neuropathy (CIPN) have not been adequately considered to date due to primarily cross-sectional study designs. Our objective was to comprehensively analyze postural control during and after neurotoxic chemotherapy, and to identify potential CIPN-independent predictors for its impairment. Postural control and CIPN symptoms (EORTC QLQ-CIPN20) were longitudinally assessed before, during and three weeks after neurotoxic chemotherapy, and in three and six months follow-up examinations (N = 54). The influence of peripheral nerve function as determined by nerve conduction studies (NCS: compound motor action potentials (CMAP) and sensory action potentials (SNAP)), physical activity, and muscle strength on the change in postural control during and after chemotherapy was analyzed by multiple linear regression adjusted for age and body mass index. Postural control, CIPN signs/symptoms, and CMAP/SNAP amplitudes significantly deteriorated during chemotherapy (p < .01). During follow-up, patients recovered from postural instabilities (p < .01), whereas CIPN signs/symptoms and pathologic NCS findings persisted compared to baseline (p < .001). The regression model showed that low CMAP and high SNAP amplitudes at baseline predicted impairment of postural control during but not after chemotherapy. Hence, pre-therapeutically disturbed somatosensory inputs may induce adaptive processes that have compensatory effects and allow recovery of postural control while CIPN signs/symptoms and pathologic peripheral nerve function persist. Baseline NCS findings in cancer patients who receive neurotoxic chemotherapy thus might assist in delineating individual CIPN risk profiles more precisely to which specific exercise intervention programs could be tailor-made.Jana MüllerCharlotte KreutzSteffen RinghofMaximilian KoeppelNikolaus KleindienstGeorges SamAndreas SchneeweissJoachim WiskemannMarkus WeilerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jana Müller Charlotte Kreutz Steffen Ringhof Maximilian Koeppel Nikolaus Kleindienst Georges Sam Andreas Schneeweiss Joachim Wiskemann Markus Weiler Chemotherapy-induced peripheral neuropathy: longitudinal analysis of predictors for postural control
description	Abstract Impaired postural control is often observed in response to neurotoxic chemotherapy. However, potential explanatory factors other than chemotherapy-induced peripheral neuropathy (CIPN) have not been adequately considered to date due to primarily cross-sectional study designs. Our objective was to comprehensively analyze postural control during and after neurotoxic chemotherapy, and to identify potential CIPN-independent predictors for its impairment. Postural control and CIPN symptoms (EORTC QLQ-CIPN20) were longitudinally assessed before, during and three weeks after neurotoxic chemotherapy, and in three and six months follow-up examinations (N = 54). The influence of peripheral nerve function as determined by nerve conduction studies (NCS: compound motor action potentials (CMAP) and sensory action potentials (SNAP)), physical activity, and muscle strength on the change in postural control during and after chemotherapy was analyzed by multiple linear regression adjusted for age and body mass index. Postural control, CIPN signs/symptoms, and CMAP/SNAP amplitudes significantly deteriorated during chemotherapy (p < .01). During follow-up, patients recovered from postural instabilities (p < .01), whereas CIPN signs/symptoms and pathologic NCS findings persisted compared to baseline (p < .001). The regression model showed that low CMAP and high SNAP amplitudes at baseline predicted impairment of postural control during but not after chemotherapy. Hence, pre-therapeutically disturbed somatosensory inputs may induce adaptive processes that have compensatory effects and allow recovery of postural control while CIPN signs/symptoms and pathologic peripheral nerve function persist. Baseline NCS findings in cancer patients who receive neurotoxic chemotherapy thus might assist in delineating individual CIPN risk profiles more precisely to which specific exercise intervention programs could be tailor-made.
format	article
author	Jana Müller Charlotte Kreutz Steffen Ringhof Maximilian Koeppel Nikolaus Kleindienst Georges Sam Andreas Schneeweiss Joachim Wiskemann Markus Weiler
author_facet	Jana Müller Charlotte Kreutz Steffen Ringhof Maximilian Koeppel Nikolaus Kleindienst Georges Sam Andreas Schneeweiss Joachim Wiskemann Markus Weiler
author_sort	Jana Müller
title	Chemotherapy-induced peripheral neuropathy: longitudinal analysis of predictors for postural control
title_short	Chemotherapy-induced peripheral neuropathy: longitudinal analysis of predictors for postural control
title_full	Chemotherapy-induced peripheral neuropathy: longitudinal analysis of predictors for postural control
title_fullStr	Chemotherapy-induced peripheral neuropathy: longitudinal analysis of predictors for postural control
title_full_unstemmed	Chemotherapy-induced peripheral neuropathy: longitudinal analysis of predictors for postural control
title_sort	chemotherapy-induced peripheral neuropathy: longitudinal analysis of predictors for postural control
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/de6be1994d5f4fb194f743552100ecce
work_keys_str_mv	AT janamuller chemotherapyinducedperipheralneuropathylongitudinalanalysisofpredictorsforposturalcontrol AT charlottekreutz chemotherapyinducedperipheralneuropathylongitudinalanalysisofpredictorsforposturalcontrol AT steffenringhof chemotherapyinducedperipheralneuropathylongitudinalanalysisofpredictorsforposturalcontrol AT maximiliankoeppel chemotherapyinducedperipheralneuropathylongitudinalanalysisofpredictorsforposturalcontrol AT nikolauskleindienst chemotherapyinducedperipheralneuropathylongitudinalanalysisofpredictorsforposturalcontrol AT georgessam chemotherapyinducedperipheralneuropathylongitudinalanalysisofpredictorsforposturalcontrol AT andreasschneeweiss chemotherapyinducedperipheralneuropathylongitudinalanalysisofpredictorsforposturalcontrol AT joachimwiskemann chemotherapyinducedperipheralneuropathylongitudinalanalysisofpredictorsforposturalcontrol AT markusweiler chemotherapyinducedperipheralneuropathylongitudinalanalysisofpredictorsforposturalcontrol
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Chemotherapy-induced peripheral neuropathy: longitudinal analysis of predictors for postural control

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