Cerebellar disruption impairs working memory during evidence accumulation

Disruption of cerebellar activity impairs working memory during evidence accumulation in mice. Here, the authors show that optogenetic perturbation of Purkinje cell activity disrupts the accurate accumulation of somatosensory information in working memory during perceptual decision-making.

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Auteurs principaux: Ben Deverett, Mikhail Kislin, David W. Tank, Samuel S.-H. Wang
Format: article
Langue:EN
Publié: Nature Portfolio 2019
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Accès en ligne:https://doaj.org/article/de6e44beedb043dfbf9f02ffc63f0b8e
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Résumé:Disruption of cerebellar activity impairs working memory during evidence accumulation in mice. Here, the authors show that optogenetic perturbation of Purkinje cell activity disrupts the accurate accumulation of somatosensory information in working memory during perceptual decision-making.