Biomimetic Nanomaterials Triggered Ferroptosis for Cancer Theranostics

Ferroptosis, as a recently discovered non-apoptotic programmed cell death with an iron-dependent form, has attracted great attention in the field of cancer nanomedicine. However, many ferroptosis-related nano-inducers encountered unexpected limitations such as immune exposure, low circulation time,...

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Autores principales:	Xinyu Zhang, Yanling Ma, Jipeng Wan, Jia Yuan, Diqing Wang, Weiyi Wang, Xiao Sun, Qingwei Meng
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	biomimetic modification nanomedicine ferroptosis diagnosis cancer therapy Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/de6ebf63e3e4447faba09af47c5a086b
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spelling	oai:doaj.org-article:de6ebf63e3e4447faba09af47c5a086b2021-11-16T07:05:47ZBiomimetic Nanomaterials Triggered Ferroptosis for Cancer Theranostics2296-264610.3389/fchem.2021.768248https://doaj.org/article/de6ebf63e3e4447faba09af47c5a086b2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fchem.2021.768248/fullhttps://doaj.org/toc/2296-2646Ferroptosis, as a recently discovered non-apoptotic programmed cell death with an iron-dependent form, has attracted great attention in the field of cancer nanomedicine. However, many ferroptosis-related nano-inducers encountered unexpected limitations such as immune exposure, low circulation time, and ineffective tumor targeting. Biomimetic nanomaterials possess some unique physicochemical properties which can achieve immune escape and effective tumor targeting. Especially, certain components of biomimetic nanomaterials can further enhance ferroptosis. Therefore, this review will provide a comprehensive overview on recent developments of biomimetic nanomaterials in ferroptosis-related cancer nanomedicine. First, the definition and character of ferroptosis and its current applications associated with chemotherapy, radiotherapy, and immunotherapy for enhancing cancer theranostics were briefly discussed. Subsequently, the advantages and limitations of some representative biomimetic nanomedicines, including biomembranes, proteins, amino acids, polyunsaturated fatty acids, and biomineralization-based ferroptosis nano-inducers, were further spotlighted. This review would therefore help the spectrum of advanced and novice researchers who are interested in this area to quickly zoom in the essential information and glean some provoking ideas to advance this subfield in cancer nanomedicine.Xinyu ZhangYanling MaJipeng WanJia YuanDiqing WangWeiyi WangXiao SunQingwei MengFrontiers Media S.A.articlebiomimetic modificationnanomedicineferroptosisdiagnosiscancer therapyChemistryQD1-999ENFrontiers in Chemistry, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	biomimetic modification nanomedicine ferroptosis diagnosis cancer therapy Chemistry QD1-999
spellingShingle	biomimetic modification nanomedicine ferroptosis diagnosis cancer therapy Chemistry QD1-999 Xinyu Zhang Yanling Ma Jipeng Wan Jia Yuan Diqing Wang Weiyi Wang Xiao Sun Qingwei Meng Biomimetic Nanomaterials Triggered Ferroptosis for Cancer Theranostics
description	Ferroptosis, as a recently discovered non-apoptotic programmed cell death with an iron-dependent form, has attracted great attention in the field of cancer nanomedicine. However, many ferroptosis-related nano-inducers encountered unexpected limitations such as immune exposure, low circulation time, and ineffective tumor targeting. Biomimetic nanomaterials possess some unique physicochemical properties which can achieve immune escape and effective tumor targeting. Especially, certain components of biomimetic nanomaterials can further enhance ferroptosis. Therefore, this review will provide a comprehensive overview on recent developments of biomimetic nanomaterials in ferroptosis-related cancer nanomedicine. First, the definition and character of ferroptosis and its current applications associated with chemotherapy, radiotherapy, and immunotherapy for enhancing cancer theranostics were briefly discussed. Subsequently, the advantages and limitations of some representative biomimetic nanomedicines, including biomembranes, proteins, amino acids, polyunsaturated fatty acids, and biomineralization-based ferroptosis nano-inducers, were further spotlighted. This review would therefore help the spectrum of advanced and novice researchers who are interested in this area to quickly zoom in the essential information and glean some provoking ideas to advance this subfield in cancer nanomedicine.
format	article
author	Xinyu Zhang Yanling Ma Jipeng Wan Jia Yuan Diqing Wang Weiyi Wang Xiao Sun Qingwei Meng
author_facet	Xinyu Zhang Yanling Ma Jipeng Wan Jia Yuan Diqing Wang Weiyi Wang Xiao Sun Qingwei Meng
author_sort	Xinyu Zhang
title	Biomimetic Nanomaterials Triggered Ferroptosis for Cancer Theranostics
title_short	Biomimetic Nanomaterials Triggered Ferroptosis for Cancer Theranostics
title_full	Biomimetic Nanomaterials Triggered Ferroptosis for Cancer Theranostics
title_fullStr	Biomimetic Nanomaterials Triggered Ferroptosis for Cancer Theranostics
title_full_unstemmed	Biomimetic Nanomaterials Triggered Ferroptosis for Cancer Theranostics
title_sort	biomimetic nanomaterials triggered ferroptosis for cancer theranostics
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/de6ebf63e3e4447faba09af47c5a086b
work_keys_str_mv	AT xinyuzhang biomimeticnanomaterialstriggeredferroptosisforcancertheranostics AT yanlingma biomimeticnanomaterialstriggeredferroptosisforcancertheranostics AT jipengwan biomimeticnanomaterialstriggeredferroptosisforcancertheranostics AT jiayuan biomimeticnanomaterialstriggeredferroptosisforcancertheranostics AT diqingwang biomimeticnanomaterialstriggeredferroptosisforcancertheranostics AT weiyiwang biomimeticnanomaterialstriggeredferroptosisforcancertheranostics AT xiaosun biomimeticnanomaterialstriggeredferroptosisforcancertheranostics AT qingweimeng biomimeticnanomaterialstriggeredferroptosisforcancertheranostics
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Biomimetic Nanomaterials Triggered Ferroptosis for Cancer Theranostics

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