IFNL4 ss469415590 variant shows similar performance to rs12979860 as predictor of response to treatment against Hepatitis C Virus genotype 1 or 4 in Caucasians.

<h4>Objectives</h4>The rs12979860 variant, linked to IL28B gene, predicts sustained viral response (SVR) to pegylated-interferon/ribavirin (pegIFN/RBV) therapy in Hepatitis C Virus genotype 1 or 4 (HCV-1/4)-infected patients. Recently, a functional variant, ss469415590, in linkage disequ...

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Autores principales:	Luis M Real, Karin Neukam, Rocío Herrero, Josep M Guardiola, Thomas Reiberger, Antonio Rivero-Juarez, Juliana Salazar, Mattias Mandorfer, Dolores Merino, Vicente Soriano, Antonio Rivero, Juan Macías, Juan A Pineda, Antonio Caruz
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/de6f613c61a94af99f5f7688fb8f44dd
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spelling	oai:doaj.org-article:de6f613c61a94af99f5f7688fb8f44dd2021-11-18T08:22:20ZIFNL4 ss469415590 variant shows similar performance to rs12979860 as predictor of response to treatment against Hepatitis C Virus genotype 1 or 4 in Caucasians.1932-620310.1371/journal.pone.0095515https://doaj.org/article/de6f613c61a94af99f5f7688fb8f44dd2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24748394/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objectives</h4>The rs12979860 variant, linked to IL28B gene, predicts sustained viral response (SVR) to pegylated-interferon/ribavirin (pegIFN/RBV) therapy in Hepatitis C Virus genotype 1 or 4 (HCV-1/4)-infected patients. Recently, a functional variant, ss469415590, in linkage disequilibrium (LD) with rs12979860, has been discovered. Our objective was to assess the value of ss469415590 to predict SVR to pegIFN/RBV in Caucasian HCV-1/4-infected individuals and to compare its performance with that of rs12979860.<h4>Methods</h4>272 Caucasian HCV-1/4-infected patients who completed a course of pegIFN/RBV were genotyped for both rs12979860 and ss469415590 markers. Logistic regression models including factors with univariate association with SVR and each genetic marker were elaborated. The area under the receiver operating-characteristic curve (AUROC) was calculated for each model and both were compared.<h4>Results</h4>Both markers were in LD (r2 = 0.82). For rs12979860, 66 (64.0%) CC versus 56 (33.1%) T allele carriers achieved SVR (Adjusted OR = 4.156, 95%CI = 2.388-7.232, p = 4.647×10-7). For ss469415590, 66 (66.0%) TT/TT versus 56 (32.5%) -G allele carriers (Adjusted OR = 4.783, 95%CI = 2.714-8.428, p = 6.153×10-8) achieved SVR. The AUROC of the model including rs12979860 was 0.742 (95%CI = 0.672-0.813) and of that based on ss469415590 was 0.756 (95%CI = 0.687-0.826) (p = 0.780).<h4>Conclusions</h4>The ss469415590 variant shows an equivalent performance to predict SVR to pegIFN/RBV than the rs2979860 in Caucasian HCV-1/4-infected patients.Luis M RealKarin NeukamRocío HerreroJosep M GuardiolaThomas ReibergerAntonio Rivero-JuarezJuliana SalazarMattias MandorferDolores MerinoVicente SorianoAntonio RiveroJuan MacíasJuan A PinedaAntonio CaruzPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 4, p e95515 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Luis M Real Karin Neukam Rocío Herrero Josep M Guardiola Thomas Reiberger Antonio Rivero-Juarez Juliana Salazar Mattias Mandorfer Dolores Merino Vicente Soriano Antonio Rivero Juan Macías Juan A Pineda Antonio Caruz IFNL4 ss469415590 variant shows similar performance to rs12979860 as predictor of response to treatment against Hepatitis C Virus genotype 1 or 4 in Caucasians.
description	<h4>Objectives</h4>The rs12979860 variant, linked to IL28B gene, predicts sustained viral response (SVR) to pegylated-interferon/ribavirin (pegIFN/RBV) therapy in Hepatitis C Virus genotype 1 or 4 (HCV-1/4)-infected patients. Recently, a functional variant, ss469415590, in linkage disequilibrium (LD) with rs12979860, has been discovered. Our objective was to assess the value of ss469415590 to predict SVR to pegIFN/RBV in Caucasian HCV-1/4-infected individuals and to compare its performance with that of rs12979860.<h4>Methods</h4>272 Caucasian HCV-1/4-infected patients who completed a course of pegIFN/RBV were genotyped for both rs12979860 and ss469415590 markers. Logistic regression models including factors with univariate association with SVR and each genetic marker were elaborated. The area under the receiver operating-characteristic curve (AUROC) was calculated for each model and both were compared.<h4>Results</h4>Both markers were in LD (r2 = 0.82). For rs12979860, 66 (64.0%) CC versus 56 (33.1%) T allele carriers achieved SVR (Adjusted OR = 4.156, 95%CI = 2.388-7.232, p = 4.647×10-7). For ss469415590, 66 (66.0%) TT/TT versus 56 (32.5%) -G allele carriers (Adjusted OR = 4.783, 95%CI = 2.714-8.428, p = 6.153×10-8) achieved SVR. The AUROC of the model including rs12979860 was 0.742 (95%CI = 0.672-0.813) and of that based on ss469415590 was 0.756 (95%CI = 0.687-0.826) (p = 0.780).<h4>Conclusions</h4>The ss469415590 variant shows an equivalent performance to predict SVR to pegIFN/RBV than the rs2979860 in Caucasian HCV-1/4-infected patients.
format	article
author	Luis M Real Karin Neukam Rocío Herrero Josep M Guardiola Thomas Reiberger Antonio Rivero-Juarez Juliana Salazar Mattias Mandorfer Dolores Merino Vicente Soriano Antonio Rivero Juan Macías Juan A Pineda Antonio Caruz
author_facet	Luis M Real Karin Neukam Rocío Herrero Josep M Guardiola Thomas Reiberger Antonio Rivero-Juarez Juliana Salazar Mattias Mandorfer Dolores Merino Vicente Soriano Antonio Rivero Juan Macías Juan A Pineda Antonio Caruz
author_sort	Luis M Real
title	IFNL4 ss469415590 variant shows similar performance to rs12979860 as predictor of response to treatment against Hepatitis C Virus genotype 1 or 4 in Caucasians.
title_short	IFNL4 ss469415590 variant shows similar performance to rs12979860 as predictor of response to treatment against Hepatitis C Virus genotype 1 or 4 in Caucasians.
title_full	IFNL4 ss469415590 variant shows similar performance to rs12979860 as predictor of response to treatment against Hepatitis C Virus genotype 1 or 4 in Caucasians.
title_fullStr	IFNL4 ss469415590 variant shows similar performance to rs12979860 as predictor of response to treatment against Hepatitis C Virus genotype 1 or 4 in Caucasians.
title_full_unstemmed	IFNL4 ss469415590 variant shows similar performance to rs12979860 as predictor of response to treatment against Hepatitis C Virus genotype 1 or 4 in Caucasians.
title_sort	ifnl4 ss469415590 variant shows similar performance to rs12979860 as predictor of response to treatment against hepatitis c virus genotype 1 or 4 in caucasians.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/de6f613c61a94af99f5f7688fb8f44dd
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IFNL4 ss469415590 variant shows similar performance to rs12979860 as predictor of response to treatment against Hepatitis C Virus genotype 1 or 4 in Caucasians.

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