Changes in metabolic syndrome status and risk of laryngeal cancer: A nationwide cohort study.

<h4>Background</h4>Whether dynamic changes of metabolic syndrome (MetS) affects the subsequent laryngeal cancer occurrence remains unknown.<h4>Objective</h4>This study investigated the effects of changes of MetS on the incidence of laryngeal cancer due to a lack of knowledge...

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Autores principales:	Hyun-Bum Kim, Geun-Jeon Kim, Kyung-do Han, Young-Hoon Joo
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/de82992e5dfd4473bd9db55dd2da586a
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spelling	oai:doaj.org-article:de82992e5dfd4473bd9db55dd2da586a2021-12-02T20:11:00ZChanges in metabolic syndrome status and risk of laryngeal cancer: A nationwide cohort study.1932-620310.1371/journal.pone.0252872https://doaj.org/article/de82992e5dfd4473bd9db55dd2da586a2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0252872https://doaj.org/toc/1932-6203<h4>Background</h4>Whether dynamic changes of metabolic syndrome (MetS) affects the subsequent laryngeal cancer occurrence remains unknown.<h4>Objective</h4>This study investigated the effects of changes of MetS on the incidence of laryngeal cancer due to a lack of knowledge regarding the development of MetS in Korean population.<h4>Methods</h4>A total of 6,757,048 individuals who received national health checkup in 2009 and follow-up health examination in 2011 were analyzed and followed up until 2018. MetS status included the following categories: MetS-chronic (n = 941,609), MetS-developed (n = 614,229), MetS-recovery (n = 455,835), and MetS-free (n = 4,745,375).<h4>Results</h4>With a median follow-up duration of 6.403 years, 1,350 subjects were newly diagnosed with laryngeal cancer. Compared to participants without MetS, adjusted hazard ratios (HR) (95% confidence interval) for those with MetS were 1.320 (1.17-1.489) for laryngeal cancer. The HR of laryngeal cancer was found to be increased with increasing number of MetS components. The MetS-developed group had a significantly higher risk of laryngeal cancer than the MetS-free group (HR: 1.296; 95% CI: 1.093-1.537). The MetS-recovery group within two years also had an increased risk of laryngeal cancer compared with the MetS-free group (HR: 1.220; 95% CI: 1.008-1.476). Among MetS components, abdominal obesity had the highest risk of laryngeal cancer (HR: 1.374; 95% CI: 1.123-1.681).<h4>Conclusion</h4>Changes in MetS status were associated with the risk of laryngeal cancer. Results of this study have implications for etiological investigations and prevention strategies.Hyun-Bum KimGeun-Jeon KimKyung-do HanYoung-Hoon JooPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0252872 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hyun-Bum Kim Geun-Jeon Kim Kyung-do Han Young-Hoon Joo Changes in metabolic syndrome status and risk of laryngeal cancer: A nationwide cohort study.
description	<h4>Background</h4>Whether dynamic changes of metabolic syndrome (MetS) affects the subsequent laryngeal cancer occurrence remains unknown.<h4>Objective</h4>This study investigated the effects of changes of MetS on the incidence of laryngeal cancer due to a lack of knowledge regarding the development of MetS in Korean population.<h4>Methods</h4>A total of 6,757,048 individuals who received national health checkup in 2009 and follow-up health examination in 2011 were analyzed and followed up until 2018. MetS status included the following categories: MetS-chronic (n = 941,609), MetS-developed (n = 614,229), MetS-recovery (n = 455,835), and MetS-free (n = 4,745,375).<h4>Results</h4>With a median follow-up duration of 6.403 years, 1,350 subjects were newly diagnosed with laryngeal cancer. Compared to participants without MetS, adjusted hazard ratios (HR) (95% confidence interval) for those with MetS were 1.320 (1.17-1.489) for laryngeal cancer. The HR of laryngeal cancer was found to be increased with increasing number of MetS components. The MetS-developed group had a significantly higher risk of laryngeal cancer than the MetS-free group (HR: 1.296; 95% CI: 1.093-1.537). The MetS-recovery group within two years also had an increased risk of laryngeal cancer compared with the MetS-free group (HR: 1.220; 95% CI: 1.008-1.476). Among MetS components, abdominal obesity had the highest risk of laryngeal cancer (HR: 1.374; 95% CI: 1.123-1.681).<h4>Conclusion</h4>Changes in MetS status were associated with the risk of laryngeal cancer. Results of this study have implications for etiological investigations and prevention strategies.
format	article
author	Hyun-Bum Kim Geun-Jeon Kim Kyung-do Han Young-Hoon Joo
author_facet	Hyun-Bum Kim Geun-Jeon Kim Kyung-do Han Young-Hoon Joo
author_sort	Hyun-Bum Kim
title	Changes in metabolic syndrome status and risk of laryngeal cancer: A nationwide cohort study.
title_short	Changes in metabolic syndrome status and risk of laryngeal cancer: A nationwide cohort study.
title_full	Changes in metabolic syndrome status and risk of laryngeal cancer: A nationwide cohort study.
title_fullStr	Changes in metabolic syndrome status and risk of laryngeal cancer: A nationwide cohort study.
title_full_unstemmed	Changes in metabolic syndrome status and risk of laryngeal cancer: A nationwide cohort study.
title_sort	changes in metabolic syndrome status and risk of laryngeal cancer: a nationwide cohort study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/de82992e5dfd4473bd9db55dd2da586a
work_keys_str_mv	AT hyunbumkim changesinmetabolicsyndromestatusandriskoflaryngealcanceranationwidecohortstudy AT geunjeonkim changesinmetabolicsyndromestatusandriskoflaryngealcanceranationwidecohortstudy AT kyungdohan changesinmetabolicsyndromestatusandriskoflaryngealcanceranationwidecohortstudy AT younghoonjoo changesinmetabolicsyndromestatusandriskoflaryngealcanceranationwidecohortstudy
_version_	1718374976244940800

Changes in metabolic syndrome status and risk of laryngeal cancer: A nationwide cohort study.

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