An Emerging Role for Calcium Signaling in Cancer-Associated Fibroblasts

Tumors exist in a complex milieu where interaction with their associated microenvironment significantly contributes to disease progression. Cancer-associated fibroblasts (CAFs) are the primary component of the tumor microenvironment and participate in complex bidirectional communication with tumor c...

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Autores principales:	Francisco Sadras, Gregory R. Monteith, Sarah J. Roberts-Thomson
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	calcium cancer cancer-associated fibroblasts migration chemoresistance Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/de8669d7f8784713aadf9d165713beaf
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spelling	oai:doaj.org-article:de8669d7f8784713aadf9d165713beaf2021-11-11T16:50:23ZAn Emerging Role for Calcium Signaling in Cancer-Associated Fibroblasts10.3390/ijms2221113661422-00671661-6596https://doaj.org/article/de8669d7f8784713aadf9d165713beaf2021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11366https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Tumors exist in a complex milieu where interaction with their associated microenvironment significantly contributes to disease progression. Cancer-associated fibroblasts (CAFs) are the primary component of the tumor microenvironment and participate in complex bidirectional communication with tumor cells. CAFs support the development of various hallmarks of cancer through diverse processes, including direct cell–cell contact, paracrine signaling, and remodeling and deposition of the extracellular matrix. Calcium signaling is a key second messenger in intra- and inter-cellular signaling pathways that contributes to cancer progression; however, the links between calcium signaling and CAFs are less well-explored. In this review, we put into context the role of calcium signaling in interactions between cancer cells and CAFs, with a focus on migration, proliferation, chemoresistance, and genetic instability.Francisco SadrasGregory R. MonteithSarah J. Roberts-ThomsonMDPI AGarticlecalciumcancercancer-associated fibroblastsmigrationchemoresistanceBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11366, p 11366 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	calcium cancer cancer-associated fibroblasts migration chemoresistance Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	calcium cancer cancer-associated fibroblasts migration chemoresistance Biology (General) QH301-705.5 Chemistry QD1-999 Francisco Sadras Gregory R. Monteith Sarah J. Roberts-Thomson An Emerging Role for Calcium Signaling in Cancer-Associated Fibroblasts
description	Tumors exist in a complex milieu where interaction with their associated microenvironment significantly contributes to disease progression. Cancer-associated fibroblasts (CAFs) are the primary component of the tumor microenvironment and participate in complex bidirectional communication with tumor cells. CAFs support the development of various hallmarks of cancer through diverse processes, including direct cell–cell contact, paracrine signaling, and remodeling and deposition of the extracellular matrix. Calcium signaling is a key second messenger in intra- and inter-cellular signaling pathways that contributes to cancer progression; however, the links between calcium signaling and CAFs are less well-explored. In this review, we put into context the role of calcium signaling in interactions between cancer cells and CAFs, with a focus on migration, proliferation, chemoresistance, and genetic instability.
format	article
author	Francisco Sadras Gregory R. Monteith Sarah J. Roberts-Thomson
author_facet	Francisco Sadras Gregory R. Monteith Sarah J. Roberts-Thomson
author_sort	Francisco Sadras
title	An Emerging Role for Calcium Signaling in Cancer-Associated Fibroblasts
title_short	An Emerging Role for Calcium Signaling in Cancer-Associated Fibroblasts
title_full	An Emerging Role for Calcium Signaling in Cancer-Associated Fibroblasts
title_fullStr	An Emerging Role for Calcium Signaling in Cancer-Associated Fibroblasts
title_full_unstemmed	An Emerging Role for Calcium Signaling in Cancer-Associated Fibroblasts
title_sort	emerging role for calcium signaling in cancer-associated fibroblasts
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/de8669d7f8784713aadf9d165713beaf
work_keys_str_mv	AT franciscosadras anemergingroleforcalciumsignalingincancerassociatedfibroblasts AT gregoryrmonteith anemergingroleforcalciumsignalingincancerassociatedfibroblasts AT sarahjrobertsthomson anemergingroleforcalciumsignalingincancerassociatedfibroblasts AT franciscosadras emergingroleforcalciumsignalingincancerassociatedfibroblasts AT gregoryrmonteith emergingroleforcalciumsignalingincancerassociatedfibroblasts AT sarahjrobertsthomson emergingroleforcalciumsignalingincancerassociatedfibroblasts
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An Emerging Role for Calcium Signaling in Cancer-Associated Fibroblasts

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